Infect Chemother.  2011 Dec;43(6):490-493. 10.3947/ic.2011.43.6.490.

A Case of Burkholderia cepacia Bacteremia and Infective Spondylitis, Treated with Ceftazidime and Trimethoprim-Sulfamethoxazole Combination Therapy, which did not Respond to Carbapenem Monotherapy

• Jang MO
• Kang HW
• Kim SE
• Kang SJ
• Jang HC
• Jung SI
• Shin JH
• Park KH

• KMID: 2170361
• DOI: http://doi.org/10.3947/ic.2011.43.6.490

Abstract

Burkholderia cepacia is an aerobic gram-negative rod that causes healthcare-associated infections through contaminated disinfectants, fluids, and medical equipment. This bacterium shows resistance to various antibiotics. For this reason, available therapeutic antimicrobial agents are limited, and the optimal antimicrobial therapeutic regimen was still not well-determined in the case of infective spondylitis. We experienced a case of B. cepacia bacteremia with infective spondylitis and paraspinal abscesses which did not respond to carbapenem monotherapy, but was did respond to ceftazidime and sulfamethoxzaole/trimethoprim combination therapy.

Keyword

Burkholderia cepacia; Spondylitis

MeSH Terms

Abscess
Anti-Bacterial Agents
Anti-Infective Agents
Bacteremia
Burkholderia
Burkholderia cepacia
Ceftazidime
Disinfectants
Spondylitis
Trimethoprim, Sulfamethoxazole Drug Combination
Anti-Bacterial Agents
Anti-Infective Agents
Ceftazidime
Disinfectants

Figure

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  Figure 1 Magnetic resonance imaging of the lumbar spine. Infective spondylitis involving L3-4, small paraspinal abscess pockets, and epidural and paraspinal soft tissue thickening was evident.

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  Figure 2 Course of the patient's hospital stay. On hospital day 13, meropenem was changed to ceftazidime plus sulfamethoxazole/trimethoprim. Then WBC count, CRP level, and fever of the patient was improved. WBC, white blood cell; CRP, c-reactive protein; BT, body temperature; CFZOL, cefazolin; MRPN, meropenem; CFTAZ, ceftazidime; SMX/TMP, sulfamethoxazole/trimethoprim.

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