Endocrinol Metab.  2015 Dec;30(4):614-619. 10.3803/EnM.2015.30.4.614.

Primary Hyperparathyroidism with Extensive Brown Tumors and Multiple Fractures in a 20-Year-Old Woman

  • 1Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea. pourlife@naver.com
  • 2Department of Otolaryngology-Head and Neck Surgery, Korea University College of Medicine, Seoul, Korea.


A brown tumor is a benign fibrotic, erosive bony lesion caused by localized, rapid osteoclastic turnover, resulting from hyperparathyroidism. Although brown tumors are one of the most pathognomonic signs of primary hyperparathyroidism, they are rarely seen in clinical practice. In this report, we present a case of 20-year-old woman with recurrent fractures and bone pain. Plain digital radiographs of the affected bones revealed multiple erosive bone tumors, which were finally diagnosed as brown tumors associated with primary hyperparathyroidism due to a parathyroid adenoma. This case shows that multiple, and clinically severe form of brown tumors can even occur in young patients.


Brown tumor; Hyperparathyroidism; Parathyroid neoplasms
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