Endocrinol Metab.  2014 Mar;29(1):77-82. 10.3803/EnM.2014.29.1.77.

Hyponatremia after Thyroid Hormone Withdrawal in a Patient with Papillary Thyroid Carcinoma

• Jo HJ
• Kim YH
• Shin DH
• Kim MJ
• Lee SJ
• Jeon DO
• Im SG
• Jang SK
• Choi JY

• KMID: 2169355
• DOI: http://doi.org/10.3803/EnM.2014.29.1.77

Abstract

Hyponatremia is an electrolyte abnormality commonly found in clinical practice. It is important to diagnose the underlying etiology of the hyponatremia and correct it appropriately because severe hyponatremia can cause serious complications and substantially increase the risk of mortality. Although hypothyroidism is known to be a cause of hyponatremia, it is rare that hyponatremia occurs in relation to hypothyroidism induced by thyroid hormone withdrawal in patients with differentiated thyroid cancer. We report a case of a 76-year-old woman with papillary thyroid carcinoma presenting with severe hyponatremia related to hypothyroidism induced by thyroid hormone withdrawal for radio-active iodine whole-body scanning, who was treated by thyroid hormone replacement and hydration. Considering that the incidence of differentiated thyroid cancer is rapidly increasing, physicians should be aware that, although uncommon, hyponatremia can occur in patients undergoing radioiodine therapy or diagnostic testing.

Keyword

Hyponatremia; Hypothyroidism; Thyroid neoplasms

MeSH Terms

Aged
Diagnostic Tests, Routine
Female
Humans
Hyponatremia*
Hypothyroidism
Incidence
Iodine
Mortality
Thyroid Gland*
Thyroid Neoplasms*
Iodine

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