Endocrinol Metab.  2011 Dec;26(4):317-323. 10.3803/EnM.2011.26.4.317.

Clinical Characteristics of Patients with Hyperglycemic Emergency State Accompanying Rhabdomyolysis

• Kim SK
• Baek JH
• Lee KJ
• Hahm JR
• Jung JH
• Kim HJ
• Kim HS
• Kim S
• Chung SI
• Jung TS

• KMID: 2169262
• DOI: http://doi.org/10.3803/EnM.2011.26.4.317

Abstract

BACKGROUND
The purpose of this study was to investigate the prevalence of rhabdomyolysis and its association with both clinical course and prognosis and to evaluate the factors associated with rhabdomyolysis in patients with hyperglycemic emergencies.
METHODS
We reviewed the medical records of patients with hyperglycemic emergencies who visited our hospital from May 2003 to April 2010. We assessed the clinical characteristics, biochemical profiles and clinical course of patients and analyzed these data according to the presence of rhabdomyolysis.
RESULTS
The prevalence of rhabdomyolysis was 29 patients (28.4%) among 102 patients. Mean serum osmolarity, glucose and serum creatinine levels were higher in patients with rhabdomyolysis than those without rhabdomyolysis. Patients with rhabdomyolysis had higher rates of hemodialysis and mortality than those without the condition. The factors associated with rhabdomyolysis in the hyperglycemic emergency state were increased serum osmolarity and APACHE II score on admission (P < 0.05).
CONCLUSION
Rhabdomyolysis commonly occurred in patients with hyperglycemic emergencies and this could aggravate their clinical course and increase mortality.

Keyword

Diabetic ketoacidosis; Hyperglycemic hyperosmolar syndrome; Rhabdomyolysis

MeSH Terms

APACHE
Creatinine
Diabetic Ketoacidosis
Emergencies
Glucose
Humans
Medical Records
Osmolar Concentration
Prevalence
Prognosis
Renal Dialysis
Rhabdomyolysis
Creatinine
Glucose

Figure

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  Fig. 1 Receiver operating characteristic curves for the prediction of the occurrence of rhabdomyolysis in hyperglycemic emergency state. A. Acute physiology and chronic health evaluation (APACHE) II score. B. Serum osmolality.

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