Allergy Asthma Respir Dis.  2015 Mar;3(2):99-104. 10.4168/aard.2015.3.2.99.

Plasma secreted phospholipase A2 in asthmatic children: correlation with leptin levels and exercise induced bronchoconstriction

• You JS
• Choi WB
• Yi YY
• Jeong SI
• Song JS
• Yang S
• Hwang IT
• Lee HB
• Baek HS

• KMID: 2168500
• DOI: http://doi.org/10.4168/aard.2015.3.2.99

Abstract

PURPOSE
Dysregulated cysteinyl leukotriene (CysLT) synthesis is prominent in exercise-induced bronchoconstriction (EIB). Secreted phospholipase A2 (sPLA2) plays a key regulatory role in the biosynthesis of CysLTs. We previously found that serum leptin levels correlate with (EIB) in children with asthma. The aim of this study was to address the relationship between plasma sPLA2/leptin levels and EIB.
METHODS
Sixty-seven prepubertal children between the ages of 6 and 10 years were included in the study. They were asthmatics with EIB (n=25), asthmatics without EIB (n=21), and healthy subjects (n=21). We measured the plasma sPLA2 and leptin levels. We also performed pulmonary function tests at baseline, after bronchodilator inhalation, and after exercise.
RESULTS
The sPLA2 and leptin levels were significantly higher in asthmatics with EIB than in those without and control subjects. In addition, sPLA2 levels were significantly correlated with body mass index (Speraman correlation coefficient r=0.343, P=0.023) and leptin levels (partial correlation coefficient r=318, P=0.033). The maximum decrease in % forced expiratory volume in 1 second after exercise was significantly correlated with both PLA2 levels (r=0.301, P=0.041) and leptin levels (r=0.346, P=0.018).
CONCLUSION
The sPLA2 and leptin levels were significantly higher in asthmatics with EIB than in asthmatics without EIB and control subjects. In addition, sPLA2 levels were significantly correlated with leptin levels and EIB in asthmatic children.

Keyword

Secreted phospholipase A2; Leptin; Exercise-induced bronchoconstriction; Asthma; Child

MeSH Terms

Asthma
Body Mass Index
Bronchoconstriction*
Child*
Forced Expiratory Volume
Humans
Inhalation
Leptin*
Phospholipases A2*
Plasma*
Respiratory Function Tests
Leptin
Phospholipases A2

Figure

• 

  Fig. 1 Levels of plasma secreted phospholipase A2 (sPLA2) of study subject. EIB, exercise-induced bronchoconstriction.

• 

  Fig. 2 Secreted phospholipase A2 (sPLA2) levels were significantly correlated with serum leptin levels in asthmatic subjects (n=46, r=0.318, P=0.033). r, partial correlation coefficient adjusted for body mass index.

• 

  Fig. 3 The maximum decreases in % forced expiratory volume in 1 second (FEV1) after exercise were significantly correlated with both phospholipase A2 levels (A: n=46, r=0.301, P=0.041) and leptin levels (B: n=46, r=0.346, P=0.018). r, partial correlation coefficient adjusted for body mass index.

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