Hanyang Med Rev.  2012 Nov;32(4):171-178. 10.7599/hmr.2012.32.4.171.

Endocrine Diseases in Diabetes Mellitus

Affiliations
  • 1Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea. parkys@hanyang.ac.kr

Abstract

The endocrine pancreas secretes several hormones including insulin and glucagon and dysfunction of them may lead to diabetes mellitus. The integrated regulation of systemic glucose balance prevents the devastating consequences of hypoglycemia and hyperglycemia. This remarkable homeostatic feat is accomplished primarily by hormones, but also by neurotransmitters and substrate effects, and it reflects the interplay of plasma glucose-lowering and glucose-raising factors. Moreover, endocrine diseases frequently co-associate with diabetes mellitus. There have also been several reports on changes in growth hormone (GH) in nutrient excess or deprivation. GH is released into the general circulation where it interacts with multiple peripheral tissues through its receptor, GH receptor, to regulate growth and metabolic function. In humans, GH levels decrease in states of nutrient excess such as obesity, and increase in response to nutrient deprivation such as fasting. Considering that GH regulates metabolism of carbohydrate, lipid, and protein, clarifying the mechanisms by which metabolic changes alter GH synthesis and secretion will increase our knowledge on the pathophysiology and treatment of metabolic diseases. In this review, the effect of nutrient excess and nutrient deficiency on GH axis function in humans will be summarized, with particular emphasis on studies exploring the direct effects of systemic signals, including insulin-like growth factor 1 (IGF-1) and insulin, on somatotrope function. Moreover, there will be a discussion over the overlap syndrome consisting of multiple endocrine neoplasm (MEN) and polyglandular autoimmune diseases (PGA).

Keyword

Diabetes Mellitus; Growth Hormone; Obesity; Fasting; Nutritional Physiological Phenomena

MeSH Terms

Autoimmune Diseases
Diabetes Mellitus
Endocrine System Diseases
Fasting
Glucagon
Glucose
Growth Hormone
Humans
Hyperglycemia
Hypoglycemia
Insulin
Islets of Langerhans
Metabolic Diseases
Neurotransmitter Agents
Nutritional Physiological Phenomena
Obesity
Plasma
Axis, Cervical Vertebra
Glucagon
Glucose
Growth Hormone
Insulin
Neurotransmitter Agents

Cited by  1 articles

Diabetes and Endocrine Disease
Ji Cheol Bae, Ji Min Han
J Korean Diabetes. 2017;18(3):155-159.    doi: 10.4093/jkd.2017.18.3.155.


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