Cancer Res Treat.  2014 Apr;46(2):204-207.

Tumor Lysis Syndrome in a Patient with Metastatic Colon Cancer after Treatment with 5-Fluorouracil/Leucovorin and Oxaliplatin: Case Report and Literature Review

• Kim HD
• Ha KS
• Woo IS
• Jung YH
• Han CW
• Kim TJ

Abstract

Development of tumor lysis syndrome (TLS) may occur after chemotherapy or spontaneously in bulky or rapidly growing tumors. This syndrome is frequent but preventable in patients with hematologic malignancies. TLS following therapy has been reported infrequently in various types of solid tumors. TLS associated with oxaliplatin containing chemotherapy in a solid tumor has never been reported. A 59-year-old man received 5-fluorouracil, leucovorin, and oxaliplatin (FOLFOX) chemotherapy for metastatic colon cancer. Development of TLS occurred three days after administration of chemotherapy. Two days later, his abnormal laboratory findings were recovered with appropriate management. To the best of our knowledge, the current case is the first report on development of acute TLS following oxaliplatin containing chemotherapy in a patient with colon cancer. We also review the literature on tumor lysis syndrome in patients with colorectal cancer.

Keyword

Tumor lysis syndrome; Oxaliplatin; Colon

MeSH Terms

Colon
Colonic Neoplasms*
Colorectal Neoplasms
Drug Therapy
Fluorouracil
Hematologic Neoplasms
Humans
Leucovorin
Middle Aged
Tumor Lysis Syndrome*
Fluorouracil
Leucovorin

Reference

1. Gemici C. Tumour lysis syndrome in solid tumours. Clin Oncol (R Coll Radiol). 2006; 18:773–780. PMID: 17168213.

2. Baeksgaard L, Sorensen JB. Acute tumor lysis syndrome in solid tumors: a case report and review of the literature. Cancer Chemother Pharmacol. 2003; 51:187–192. PMID: 12655435.

3. Mott FE, Esana A, Chakmakjian C, Herrington JD. Tumor lysis syndrome in solid tumors. Support Cancer Ther. 2005; 2:188–191. PMID: 18628171.

4. Crittenden DR, Ackerman GL. Hyperuricemic acute renal failure in disseminated carcinoma. Arch Intern Med. 1977; 137:97–99. PMID: 831657.

5. Abboud M, Shamseddine A. Maxillary sinus squamous cell carcinoma presenting with fatal tumor lysis syndrome: a case report and review of the literature. Case Rep Oncol. 2009; 2:229–233. PMID: 20737042.

6. Schuman S, Pearson JM, Lucci JA 3rd, Twiggs LB. Metastatic gestational trophoblastic neoplasia complicated by tumor lysis syndrome, heart failure, and thyrotoxicosis: a case report. J Reprod Med. 2010; 55:441–444. PMID: 21043373.

7. Michels J, Lassau N, Gross-Goupil M, Massard C, Mejean A, Escudier B. Sunitinib inducing tumor lysis syndrome in a patient treated for renal carcinoma. Invest New Drugs. 2010; 28:690–693. PMID: 19547920.

8. Lin CJ, Lim KH, Cheng YC, Chen HH, Wu CJ. Tumor lysis syndrome after treatment with gemcitabine for metastatic transitional cell carcinoma. Med Oncol. 2007; 24:455–457. PMID: 17917099.

9. Krishnan G, D'Silva K, Al-Janadi A. Cetuximab-related tumor lysis syndrome in metastatic colon carcinoma. J Clin Oncol. 2008; 26:2406–2408. PMID: 18467734.

10. Nikolic-Tomasevic Z, Jelic S, Popov I, Radosavljevic D. Colorectal cancer: dilemmas regarding patient selection and toxicity prediction. J Chemother. 2000; 12:244–251. PMID: 10877521.

11. Hentrich M, Schiel X, Scheidt B, Reitmeier M, Hoffmann U, Lutz L. Fatal tumor lysis syndrome after irinotecan/5-FU/folinic acid/bevacizumab-containing therapy in a patient heavily pretreated for metastatic colon cancer. Acta Oncol. 2008; 47:155–156. PMID: 18097781.

12. Oztop I, Demirkan B, Yaren A, Tarhan O, Sengul B, Ulukus C, et al. Rapid tumor lysis syndrome in a patient with metastatic colon cancer as a complication of treatment with 5-fluorouracil/leucoverin and irinotecan. Tumori. 2004; 90:514–516. PMID: 15656341.

13. Boisseau M, Bugat R, Mahjoubi M. Rapid tumour lysis syndrome in a metastatic colorectal cancer increased by treatment (CPT-11). Eur J Cancer. 1996; 32A:737–738. PMID: 8695285.

14. Woo IS, Kim JS, Park MJ, Lee MS, Cheon RW, Chang HM, et al. Spontaneous acute tumor lysis syndrome with advanced gastric cancer. J Korean Med Sci. 2001; 16:115–118. PMID: 11289389.

15. Howard SC, Jones DP, Pui CH. The tumor lysis syndrome. N Engl J Med. 2011; 364:1844–1854. PMID: 21561350.