Exp Neurobiol.  2015 Dec;24(4):301-311. 10.5607/en.2015.24.4.301.

New Therapeutic Options for Autism Spectrum Disorder: Experimental Evidences

• Penagarikano O

• KMID: 2165566
• DOI: http://doi.org/10.5607/en.2015.24.4.301

Abstract

Autism spectrum disorder (ASD) is characterized by impairment in two behavioral domains: social interaction/communication together with the presence of stereotyped behaviors and restricted interests. The heterogeneity in the phenotype among patients and the complex etiology of the disorder have long impeded the advancement of the development of successful pharmacotherapies. However, in the recent years, the integration of findings of multiple levels of research, from human genetics to mouse models, have made considerable progress towards the understanding of ASD pathophysiology, allowing the development of more effective targeted drug therapies. The present review discusses the current state of pharmacological research in ASD based on the emerging common pathophysiology signature.

Keyword

Autism; ASD; Pharmacotherapy; Treatment; Social behavior; Repetitive behavior

MeSH Terms

Animals
Autistic Disorder*
Child
Autism Spectrum Disorder*
Drug Therapy
Genetics, Medical
Humans
Mice
Phenotype
Population Characteristics
Social Behavior
Stereotyped Behavior