J Pathol Transl Med.  2016 May;50(3):246-249. 10.4132/jptm.2015.10.08.

Soft Tissue Roasi-Dorfman Disease with Features of IgG4-Related Disease in a Patient with a History of Acute Myeloid Leukemia

• Park CK
• Kim EK
• Kim JY
• Woo H
• Jang M
• Jeong HS
• Yang WI
• Kim SK

• KMID: 2164604
• DOI: http://doi.org/10.4132/jptm.2015.10.08

Abstract

No abstract available.

MeSH Terms

Humans
Leukemia, Myeloid, Acute*

Figure

• 

  Fig. 1. Imaging and macroscopic findings of soft tissue Rosai-Dorfman disease with features of IgG4-related disease. (A) Magnetic resonance imaging shows a 3.8×2.8 cm enhanced soft tissue mass (arrow) in the subcutaneous layer on the posteromedial side of the right mid-thigh, suggestive of leukemic infiltration. (B) In the excised specimen, a 3.0-cm irregular tan-white mass-like lesion is observed in the subcutis.

• 

  Fig. 2. Microscopic findings of soft tissue Rosai-Dorfman disease with features of IgG4-related disease. (A) In the scanning view, the infiltrative lesion involving the deep dermis and subcutaneous layer is noted. (B) In the low-power view, dense lymphoplasmacytic infiltration with scattered histiocytes is noted. (C) Diffuse lymphoplasmacytic infiltration is noted in the sclerotic stroma. (D) Dilated sinuses are filled with histiocytes containing intact lymphocytes (emperipolesis).

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  Fig. 3. Immunohistochemical staining results of soft tissue Rosai-Dorfman disease with features of IgG4-related disease. (A) Immunohistochemical staining for CD68 demonstrates histiocytes. (B) Immunohistochemical staining for S100 protein demonstrates emperipolesis. (C) Plasma cell IgG immunoreactivity. (D) Frequently identified IgG4-positive cells.

Reference

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