Ann Dermatol.  2000 Dec;12(4):275-279. 10.5021/ad.2000.12.4.275.

A Case of Subcutaneous Panniculitic T-cell Lymphoma

• Eim JJ
• Kim YH
• Joh GY
• Kim KH

• KMID: 2163998
• DOI: http://doi.org/10.5021/ad.2000.12.4.275

Abstract

We herein report a case of subcutaneous panniculitic T-cell lymphoma which occurred in a 48-year-old Korean woman. Her disease presented as multiple subcutaneous nodules on the arms, legs, and abdomen, with systemic symptoms and signs. From the results of immunophenotypic studies, we suggest her disease may originate from cytotoxic T-lymphocytes. The patient had a protracted course of multiple dark-red-colored subcutaneous nodules on both arms, legs, and abdomen for 1 year, often with fever, chills, and malaise. Histopathologic findings for the subcutaneous nodule in the lower abdomen revealed diffuse infiltration of atypical lymphocytes in the subcutis, with extensive fat necrosis and karyorrhexis and a bean-bag cell appearance with engulfed lymphocytes in some histiocytes. The immunophenotypic studies showed a cytotoxic T-lymphocyte profile, i. e., LCA+, lysozyme+, UCHL1+, CD8+, CD20-, CD30-, and CD56-. In situ hybridization studies for the Epstein-Barr virus genome resulted in a negative finding. A lymphadenopathy was found in the right upper paratracheal area on the chest CT associated with pancytopenia and abnormal LFT findings. She received high-dose chemotherapy with autologous blood stem cell transplantation, but died after 6 months.

Keyword

Subcutaneous panniculitic T-cell lymphoma; Cutaneous T-cell lymphoma

MeSH Terms

Abdomen
Arm
Chills
Drug Therapy
Fat Necrosis
Female
Fever
Genome
Glycogen Storage Disease Type VI
Herpesvirus 4, Human
Histiocytes
Humans
In Situ Hybridization
Leg
Lymphatic Diseases
Lymphocytes
Lymphoma, T-Cell*
Lymphoma, T-Cell, Cutaneous
Middle Aged
Pancytopenia
Stem Cell Transplantation
T-Lymphocytes*
T-Lymphocytes, Cytotoxic
Tomography, X-Ray Computed