Korean J Intern Med.
2016 May;31(3):517-524. 10.3904/kjim.2015.095.
A prospective cohort study of latent tuberculosis in adult close contacts of active pulmonary tuberculosis patients in Korea
- Affiliations
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- 1Department of Internal Medicine, Dongnam Institute of Radiological & Medical Sciences Cancer Center, Busan, Korea.
- 2Department of Internal Medicine, Gyeongsang National University School of Medicine, Jinju, Korea. hockkim@gnu.ac.kr
- 3Gyeongsang Institute of Health Sciences, Gyeongsang National University, Jinju, Korea.
- 4Korean Institute of Tuberculosis, Seoul, Korea.
- 5Montreal Chest Institute, McGill University, Montreal, QC, Canada.
- KMID: 2163508
- DOI: http://doi.org/10.3904/kjim.2015.095
Abstract
- BACKGROUND/AIMS
The objective of this prospective study was to evaluate the diagnosis and treatment of latent tuberculosis infection (LTBI) in adult close contacts of active pulmonary tuberculosis (TB) patients in Korea.
METHODS
Adult close contacts of active pulmonary TB patients were recruited at a regional tertiary hospital in Korea. The participants were tested for LTBI using the tuberculin skin test (TST) and/or QuantiFERON-TB Gold (QFT-G) test. LTBI patients, who consented to treatment, were randomly assigned to receive isoniazid for 9 months (9INH) or rifampin for 4 months (4RIF).
RESULTS
We examined 189 adult close contacts (> 18 years) of 107 active pulmonary TB patients. The TST and QFT-G were positive (≥ 10 mm) in 75/183 (39.7%) and 45/118 (38.1%) tested participants, respectively. Among 88 TST or QFT-G positive LTBI participants, 45 participants were randomly assigned to receive 4RIF (n = 21) or 9INH (n = 24), respectively. The average treatment duration for the 4RIF and 9INH groups was 3.3 ± 1.3 and 6.1 ± 2.7 months, respectively. Treatment was completed in 25 participants (4RIF, n = 16; 9INH, n = 9). LTBI participants who accepted treatment were more likely to be women and have more cavitary lesions on the chest radiographs of index cases and positive TST and QFT-G results compared to those who refused treatment.
CONCLUSIONS
About 40% of adult close contacts of active pulmonary TB patients had LTBI; about 50% of these LTBI participants agreed to treatment.
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