Clin Exp Reprod Med.  2016 Mar;43(1):1-8. 10.5653/cerm.2016.43.1.1.

Insights into granulosa cell tumors using spontaneous or genetically engineered mouse models

• Kim SY

• KMID: 2161355
• DOI: http://doi.org/10.5653/cerm.2016.43.1.1

Abstract

Granulosa cell tumors (GCTs) are rare sex cord-stromal tumors that have been studied for decades. However, their infrequency has delayed efforts to research their etiology. Recently, mutations in human GCTs have been discovered, which has led to further research aimed at determining the molecular mechanisms underlying the disease. Mouse models have been important tools for studying GCTs, and have provided means to develop and improve diagnostics and therapeutics. Thus far, several genetically modified mouse models, along with one spontaneous mouse model, have been reported. This review summarizes the phenotypes of these mouse models and their applicability in elucidating the mechanisms of granulosa cell tumor development.

Keyword

Adult granulosa cell tumor; Animal Models; Granulosa cell tumor; Juvenile granulosa cell tumor

MeSH Terms

Animals
Female
Granulosa Cell Tumor*
Granulosa Cells*
Humans
Mice*
Models, Animal
Phenotype
Sex Cord-Gonadal Stromal Tumors