J Vet Sci.  2015 Mar;16(1):127-130. 10.4142/jvs.2015.16.1.127.

Application of vincristine-loaded platelet therapy in three dogs with refractory immune-mediated thrombocytopenia

• Park HJ
• Kim JW
• Song KH
• Seo KW

• KMID: 2160830
• DOI: http://doi.org/10.4142/jvs.2015.16.1.127

Abstract

Three dogs presented with refractory immune-mediated thrombocytopenia (IMT). All patients failed to respond to prednisone, which is considered a mainstay of immunosuppressive therapy. Vincristine-loaded platelets (VLPs), which act selectively on mononuclear phagocytes,were introduced. After the VLPs were transfused, two dogs responded quickly withimproved clinical signs while the third dogwith recurrent IMT was euthanized due to its deteriorating condition. This case report describesthe efficacy of VLP therapy in refractory IMT patients.

Keyword

refractory immune-mediated thrombocytopenia; vincristine-loaded platelets

MeSH Terms

Animals
Antineoplastic Agents, Phytogenic/administration & dosage/*therapeutic use
Dog Diseases/*therapy
Dogs
Female
Male
Platelet Transfusion/methods/*veterinary
Purpura, Thrombocytopenic, Idiopathic/therapy/*veterinary
Vincristine/administration & dosage/*therapeutic use
Antineoplastic Agents, Phytogenic
Vincristine

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