Korean J Intern Med.  2015 May;30(3):279-293. 10.3904/kjim.2015.30.3.279.

Hard tissue regeneration using bone substitutes: an update on innovations in materials

• Sarkar SK
• Lee BT

• KMID: 2160700
• DOI: http://doi.org/10.3904/kjim.2015.30.3.279

Abstract

Bone is a unique organ composed of mineralized hard tissue, unlike any other body part. The unique manner in which bone can constantly undergo self-remodeling has created interesting clinical approaches to the healing of damaged bone. Healing of large bone defects is achieved using implant materials that gradually integrate with the body after healing is completed. Such strategies require a multidisciplinary approach by material scientists, biological scientists, and clinicians. Development of materials for bone healing and exploration of the interactions thereof with the body are active research areas. In this review, we explore ongoing developments in the creation of materials for regenerating hard tissues.

Keyword

Bone substitutes; Bone tissue engineering; Bioceramics; Hydrogel; Biopolymers

MeSH Terms

Animals
Bone Regeneration/*drug effects
Bone Substitutes/*therapeutic use
Bone and Bones/*drug effects/pathology/physiopathology
Ceramics/therapeutic use
Diffusion of Innovation
Fracture Healing/drug effects
Humans
Hydrogels
Polymers/therapeutic use
Regenerative Medicine/*trends
Tissue Engineering/*trends
Treatment Outcome
Bone Substitutes
Hydrogels
Polymers