Korean J Intern Med.  2015 Mar;30(2):205-211. 10.3904/kjim.2015.30.2.205.

Relationship between duration of hospital-acquired acute kidney injury and mortality: a prospective observational study

• Yoo J
• Lee JS
• Lee J
• Jeon JS
• Noh H
• Han DC
• Kwon SH

• KMID: 2160685
• DOI: http://doi.org/10.3904/kjim.2015.30.2.205

Abstract

BACKGROUND/AIMS
New definitions of acute kidney injury (AKI) have recently emerged. Some studies have suggested that duration of AKI is an additional predictive parameter for mortality. Here, we evaluated whether AKI duration was predictive of long-term mortality in patients with hospital-acquired acute kidney injury (HAAKI).
METHODS
We prospectively enrolled patients who developed HAAKI at an urban university hospital, from September 2007 to August 2008 and followed them until December 2011. Patients were divided into two groups by duration of the AKI (1 to 5 days vs. > or = 6 days), and long-term mortality was compared.
RESULTS
HAAKI developed in 1.2% of patients during the enrollment period. The median follow-up period was 240 days (interquartile range, 53 to 1,428). In 42.3% of patients (n = 52), the AKI lasted 1 to 5 days, while it lasted > or = 6 days in 57.7% (n = 71). Survival analysis showed that a longer duration of AKI increased the risk of death. Long-term survival was significantly different in the two groups.
CONCLUSIONS
The duration of AKI influenced mortality rates in hospitalized patients. Thus, AKI duration is a parameter affecting mortality in HAAKI.

Keyword

Acute kidney injury; Duration; Mortality; Recovery; Survival

MeSH Terms

Acute Kidney Injury/diagnosis/etiology/*mortality/therapy
Aged
Female
*Hospitalization
Hospitals, University
Humans
Kaplan-Meier Estimate
Male
Middle Aged
Prognosis
Proportional Hazards Models
Prospective Studies
Republic of Korea
Risk Factors
Time Factors