Gut Liver.  2015 Jul;9(4):464-469. 10.5009/gnl14005.

Lipase Supplementation before a High-Fat Meal Reduces Perceptions of Fullness in Healthy Subjects

• Levine ME
• Koch SY
• Koch KL

• KMID: 2160629
• DOI: http://doi.org/10.5009/gnl14005

Abstract

BACKGROUND/AIMS
Postprandial symptoms of fullness and abdominal discomfort are common after fatty meals. Gastric lipases hydrolyze 10% to 20% of dietary triglycerides during the stomach trituration period of digestion. The aim of this study was to evaluate the effects of acid-resistant lipase on upper gastrointestinal symptoms, including fullness and bloating, as well as on gastric myoelectrical activity after healthy subjects ingested a high-fat, liquid meal.
METHODS
This study utilized a double-blind, placebo-controlled, crossover design with 16 healthy volunteers who ingested either a capsule containing 280 mg of acid-resistant lipase or a placebo immediately before a fatty meal (355 calories, 55% fat). Participants rated their stomach fullness, bloating, and nausea before and at timed intervals for 60 minutes after the meal. Electrogastrograms were obtained to assess the gastric myoelectrical activity.
RESULTS
Stomach fullness, bloating, and nausea increased significantly 10 minutes after ingestion of the fatty meal (p<0.01), whereas normal gastric myoelectrical activity decreased and tachygastria increased (p<0.05). With lipase, reports of stomach fullness were significantly lower compared with placebo (p<0.05), but no effect on gastric myoelectrical activity or other upper gastrointestinal symptoms was observed.
CONCLUSIONS
The high-fat meal induced transient fullness, bloating, nausea, and tachygastria in healthy individuals, consistent with post-prandial distress syndrome. Acid-resistant lipase supplementation significantly decreased stomach fullness.

Keyword

Lipase supplementation; Gastric myoelectrical activity; Electrogastrography; Dyspepsia symptoms; Fullness; Acid-resistant lipase

MeSH Terms

Abdominal Pain/etiology/psychology
Adult
Cross-Over Studies
Diet, High-Fat/*adverse effects/psychology
*Dietary Supplements
Double-Blind Method
Dyspepsia/etiology/*prevention & control/psychology
Female
Gastrointestinal Motility/drug effects/physiology
Healthy Volunteers
Humans
Lipase/*administration & dosage
Male
Meals
Middle Aged
Myoelectric Complex, Migrating
Nausea/etiology/psychology
Postprandial Period
Stomach/*drug effects/physiology
Young Adult
Lipase