Obstet Gynecol Sci.  2016 Mar;59(2):152-156. 10.5468/ogs.2016.59.2.152.

Endometrial adenocarcinoma in a 13-year-old girl

• Kim SM
• Shin SJ
• Bae JG
• Kwon KY
• Rhee JH

• KMID: 2159012
• DOI: http://doi.org/10.5468/ogs.2016.59.2.152

Abstract

Endometrial cancer is the third most common gynecologic cancer in the Korea and occurs mainly in menopausal women. Although it can develop in young premenopausal women cancer as well, an attack in the adolescent girl is very rare. A 13-year-old girl visited gynecology department with the complaint of abnormal uterine bleeding. An endometrial biopsy revealed FIGO (International Federation of Gynecology and Obstetrics) grade II endometrial adenocarcinoma. In the treatment of endometrial cancer, conservative management should be considered if the patient is nulliparous or wants the fertility preservation. Therefore, we decided to perform a hormonal therapy and a follow-up endometrial biopsy after progestin administration for eight months revealed no residual tumor. We report a case of endometrial cancer occurred in a 13-year-old girl with a brief review of the literature.

Keyword

Adolescent girl; Conservative management; Endometrial neoplasms; Fertility preservation

MeSH Terms

Adenocarcinoma*
Adolescent*
Biopsy
Endometrial Neoplasms
Female*
Fertility Preservation
Follow-Up Studies
Gynecology
Humans
Korea
Neoplasm, Residual
Uterine Hemorrhage

Figure

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  Fig. 1 Magnetic resonance imaging showing nodular mass involving the fundus and diffuse superficial infiltration along the entire posterior wall.

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  Fig. 2 Histopathologic findings of the consecutive endometrial biopsies (H&E, ×110). First biopsy shows adenocarcinoma (A) arising in the atypical complex hyperplasia (B). (C) Second biopsy shows asynchronous endometrium with only focal atypical glands and degenerated morular lesions. (D) Third biopsy shows only asynchronous endometrium with atrophic glands. Fourth biopsy shows asynchronous endometrium (E) and pseudodecidualization (F).

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