Ann Dermatol.  2004 Mar;16(1):31-38. 10.5021/ad.2004.16.1.31.

A Case of Subcutaneous Panniculitic T-cell Lymphoma in a Child

• Kim HS
• Heo KY
• Han JY
• Jung JA
• Song KH
• Kim KH

• KMID: 2158510
• DOI: http://doi.org/10.5021/ad.2004.16.1.31

Abstract

We report a case of subcutaneous panniculitic T-cell lymphoma (SPTCL) which occurred in a 10-year-old Korean girl. Her disease presented as multiple erythematous subcutaneous nodules on the right cheek, left chest, abdomen, left flank, both calves, and left shin with systemic symptoms. She had a protracted course of multiple erythematous subcutaneous nodules for 2 months often with spiking fever. Histopathologic findings for the subcutaneous nodules revealed lobular panniculitis-like findings composed of atypical small, bland lymphocytes and histiocytes. Characteristically, atypical lymphocytes rimmed individual fat cells in a lace-like pattern and some histiocytes occasionally phagocytosed WBCs. Bone marrow findings revealed increased phagocytic histiocytes with engulfed hematopoietic cell. The immunophenotypic studies showed CD45RO (UCHLl)+, CD20-, CD4-, CD8+ and CD56+ (focal), lysozyme+, CD45 (LCA)+ and EBV-. She received three cycles of high-dose cyclophosphamide, adriamycin, vincristine, prednisolone (CHOP) and methotrexate, intrathecal methotrexate and one cycle of fludarabine, mitoxantrone and dexamethasone (FND) chemotherapy. She died of acute renal failure during multiple chemotherapy.

Keyword

Subcutaneous panniculitic T-cell lymphoma; Cutaneous T-cell lymphoma; Cytophagic histiocytic panniculitis; Hemophagocytosis

MeSH Terms

Abdomen
Acute Kidney Injury
Adipocytes
Bone Marrow
Cheek
Child*
Cyclophosphamide
Dexamethasone
Doxorubicin
Drug Therapy
Female
Fever
Glycogen Storage Disease Type VI
Histiocytes
Humans
Lymphocytes
Lymphoma, T-Cell*
Lymphoma, T-Cell, Cutaneous
Methotrexate
Mitoxantrone
Prednisolone
T-Lymphocytes*
Thorax
Vincristine
Cyclophosphamide
Dexamethasone
Doxorubicin
Methotrexate
Mitoxantrone
Prednisolone
Vincristine