Yonsei Med J.  2008 Oct;49(5):742-747. 10.3349/ymj.2008.49.5.742.

The Effects of Etodolac, Nimesulid and Naproxen Sodium on the Frequency of Sister Chromatid Exchange after Enclused Third Molars Surgery

• Koseoglu B
• Ozturk S
• Kocak H
• Palanduz S
• Cefle K

• KMID: 2158192
• DOI: http://doi.org/10.3349/ymj.2008.49.5.742

Abstract

PURPOSE
Non-steroidal anti-inflammatory drugs (NSAID) are frequently used in oral surgical procedures in dentistry. The evaluation of the frequency of sister chromatid exchange (SCE) is accepted as a reliable cytogenetic method to assess the genotoxic effects of environmental factors. MATERIALS AND METHODS: In this study, the genotoxic effects of various NSAIDs were assessed in 30 patients to who they were administered following encluosed third molar surgery using SCE analysis before and after the operation. The frequency of SCE was evaluated before the operation and after 3 days of etodolac, nimesulid and naproxen use. RESULTS: There was no statistically significant difference in the frequency of SCE between the preoperative and postoperative states in patients given etodolac, nimesulid or naproxen sodium. CONCLUSION: Short term use of selective and non-selective NSAIDs was not associated with a significant genotoxic effect that could be detected using the SCE method in peripheric lymphocytes.

Keyword

Genotoxicity; sister chromatid exchange; oral surgery; non-steroidal anti-inflammatory drugs

MeSH Terms

Adult
Anti-Inflammatory Agents, Non-Steroidal/*adverse effects
Etodolac/adverse effects
Female
Humans
Male
Molar, Third/*surgery
Mutagenicity Tests
Naproxen/adverse effects
Prospective Studies
Sister Chromatid Exchange/*drug effects
Sulfonamides/adverse effects

Figure

• 

  Fig. 1 In the normal state, one of the sister chromatids is stained dark, while the other is stained light. When a reciprocal change occurs, a dark segment and its homologue light counterpart change places leading to alternating dark and light regions throughout the chromatids.

• 

  Fig. 2 Comparison of sister chromatid exchange frequencies was performed between the preoperative and postoperative values for etodolac, nimesulid and naproxen sodium.

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