J Korean Med Sci.  2012 Nov;27(11):1320-1326. 10.3346/jkms.2012.27.11.1320.

Cord Blood Cellular Proliferative Response as a Predictive Factor for Atopic Dermatitis at 12 Months

• Kim HB
• Ahn KM
• Kim KW
• Shin YH
• Yu J
• Seo JH
• Kim HY
• Kwon JW
• Kim BJ
• Kwon JY
• Choi SJ
• Lee KJ
• Park HJ
• Won HS
• Hong SJ

• KMID: 2157941
• DOI: http://doi.org/10.3346/jkms.2012.27.11.1320

Abstract

Since the risk of developing allergic disease increases in individuals exposed to allergens previously, even during the neonatal period, the immunologic status of a fetus may be important in the subsequent development of allergy. We evaluated the fetal factors to predict atopic dermatitis (AD) at 12 months in 412 infants of a COhort for Childhood Origin of Asthma and Allergic Diseases (COCOA) in the general Korean population. Cord blood mononuclear cells (CBMCs) were stimulated with ovalbumin and phytohemagglutinin and cellular proliferative response and concentrations of interleukin-13 and interferon-gamma, were measured. The risk of developing AD was greater in boys than girls (OR 1.97, 95% CI 1.26-3.09), infants delivered by cesarean section than vaginally (OR 1.93, 95% CI 1.14-3.26) and infants with than without parental history of AD (OR 2.34, 95% CI 1.29-4.24). The CBMC proliferative response to phytohemagglutinin stimulation was higher in infants with than without AD (P = 0.048), but no difference was observed in ovalbumin-stimulated cells (P = 0.771). Risk factors for the development of AD at 12 months include male gender, delivery by cesarean section and parental history of AD. Increased CBMC proliferative response to phytohemagglutinin stimulation may predict the development of AD at 12 months.

Keyword

Atopic Dermatitis; Cohort; Cord Blood; Cellular Proliferative Response; Cytokine; Risk Factor

MeSH Terms

Adult
Cell Proliferation
Cesarean Section
Dermatitis, Atopic/*diagnosis/metabolism
Female
Fetal Blood/*cytology/metabolism
Humans
Infant
Interferon-gamma/metabolism
Interleukin-13/metabolism
Leukocytes, Mononuclear/drug effects/*metabolism
Male
Odds Ratio
Ovalbumin/toxicity
Phytohemagglutinins/toxicity
Predictive Value of Tests
Pregnancy
Risk Factors
Sex Factors
Interleukin-13
Phytohemagglutinins
Interferon-gamma
Ovalbumin

Figure

• 

  Fig. 1 Cellular proliferative responses to ovalbumin (OVA) and phytohemagglutinin (PHA) stimulation in infants with and without atopic dermatitis at 12 months. Ratio of cellular proliferative responses in the presence and absence of (A) OVA and (B) PHA. The median values are presented and differences between the groups were reported as P values.

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