J Korean Med Sci.  2003 Apr;18(2):267-271. 10.3346/jkms.2003.18.2.267.

Metabolic Changes after Revascularization in a Patient with Innominate Artery Occlusion by Localized in vivo Proton Magnetic Resonance Spectroscopy

• Cho YP
• Lee JH
• Kim GE

• KMID: 2157633
• DOI: http://doi.org/10.3346/jkms.2003.18.2.267

Abstract

Localized in vivo proton magnetic resonance spectroscopy (1H-MRS) has been used to measure the metabolic status of the human brain in a non-invasive manner; thus, it is often called "a non-invasive biochemical assay". MRS is more sensitive than magnetic resonance imaging (MRI) in detecting ischemic damage by measuring the metabolic changes that occur prior to the anatomic changes. We report a patient who presented with innominate artery occlusion and symptoms of posterior circulation insufficiency and showed favorable metabolic changes by 1H-MRS after revascularization. He showed no visible lesion in brain MRI, but in 1H-MRS, decreased N-acetylaspartate (NAA) signal was noted in a resting state. After revascularization, both symptomatic improvement and recovery of NAA signal were observed. 1H-MRS may provide valuable clinical information in diagnosis and management of cerebral hypoperfusion at a much earlier stage prior to the anatomic changes.

Keyword

Magnetic Resonance Spectroscopy; Brachiocephalic trunk; Arterial Occlusive Diseases; Reperfusion

MeSH Terms

Arterial Occlusive Diseases/pathology
Brachiocephalic Trunk/pathology*
Brachiocephalic Trunk/surgery
Brain/metabolism*
Cerebral Revascularization*
Human
Magnetic Resonance Imaging
Male
Middle Aged
Protons