Ann Dermatol.  2011 Sep;23(Suppl 1):S84-S87. 10.5021/ad.2011.23.S1.S84.

Eccrine Angiomatous Hamartoma Mimicking a Traumatic Hemorrhage

• Yun JH
• Kang HK
• Na SY
• Roh JY
• Lee JR

• KMID: 2156759
• DOI: http://doi.org/10.5021/ad.2011.23.S1.S84

Abstract

Eccrine angiomatous hamartoma (EAH) is a rare benign disease that is characterized by an abnormal proliferation of eccrine glands and vascular elements. It is generally congenital, but it can appear before puberty. It usually presents as a single plaque or nodule, but multiple patch-like lesions are also possible. EAH is mostly asymptomatic, but it is sometimes associated with pain or hyperhidrosis. It generally does not require aggressive treatment, but the lesion can be excised due to pain, enlargement and cosmetic reasons. A 3-week-old Korean female presented with a hemorrhagic skin lesion on the right foot since birth. There was no specific birth history. The lesion first appeared on the third toe of the right foot and quickly spread to almost half of the right foot. Histopathology examination revealed acanthosis in the epidermis and a proliferation of eccrine ducts, glands and capillaries. The eccrine glands were immunohistochemically-positive for carcinoembryonic antigen.

Keyword

Eccrine glands; Hamartoma

MeSH Terms

Capillaries
Carcinoembryonic Antigen
Cosmetics
Eccrine Glands
Epidermis
Female
Foot
Hamartoma
Hemorrhage
Humans
Hyperhidrosis
Parturition
Puberty
Reproductive History
Skin
Toes
Carcinoembryonic Antigen
Cosmetics

Figure

• 

  Fig. 1 Well-demarcated hemorrhage-like maculopatches evident on the right foot.

• 

  Fig. 2 Results from a skin biopsy. (A) The biopsy specimen shows irregular acanthosis with hyperplasia of the eccrine glands and capillaries in the mid-upper dermis (H&E, ×100). (B) Hyperplasia of the eccrine glands and capillaries associated with fatty tissue (H&E, ×200).

• 

  Fig. 3 Positive CEA immunostaining of the eccrine ducts and secretory lobules (×200).

Reference

1. Ahmed TSS, Del Priore J, Seykora JT. Elder DE, Elenitsas R, Johnson B, Loffreda M, Miller J, Miller OF, editors. Tumors of the epidermal appendages. Lever's histopathology of the skin. 2009. Philadelphia: Lippincott-Williams and Wilkins;883.

2. Pelle MT, Pride HB, Tyler WB. Eccrine angiomatous hamartoma. J Am Acad Dermatol. 2002. 47:429–435.

3. Foshee JB, Grau RH, Adelson DM, Crowson N. Eccrine angiomatous harmartoma in an infant. Pediatr Dermatol. 2006. 23:365–368.

4. Larralde M, Bazzolo E, Boggio P, Abad ME, Santos Muñoz A. Eccrine angiomatous hamartoma: report of five congenital cases. Pediatr Dermatol. 2009. 26:316–319.

5. Jeong E, Park HJ, Oh ST, Lee JY, Cho BK. Late-onset eccrine angiomatous hamartoma on the forehead. Int J Dermatol. 2006. 45:598–599.

6. Ahn KJ, Kim KJ, Lee YS. Eccrine angiomatous hamartomam: report of case. Korean J Dermatol. 1981. 19:527–531.

7. Kim ST, Kim DH, Joung SW, Jun JB. A case of eccrine angiomatous hamartoma. Korean J Dermatol. 1982. 20:623–627.

8. Kim HY, Hwang SW, Kim YP. Sudoriparous angioma: report of two cases. Korean J Dermatol. 1982. 20:885–889.

9. Choi GJ, Cho KH, Houh D, Kim HO, Kim CW. Two case of sudoriparous angioma. Korean J Dermatol. 1982. 20:957–964.

10. Lee JC, Park JJ, Jung EC, Park SR. A case of eccrine angiomatous hamartoma. Korean J Dermatol. 1988. 26:255–258.

11. Ryu HJ, Oh CH, Kim IH. Two cases of eccrine angiomatous hamartoma. Korean J Dermatol. 2002. 40:1393–1396.

12. Choi J, Chung EC. A case of eccrine angiomatous hamartoma. Korean J Dermatol. 2003. 41:951–953.

13. Yoon SY, Choi MJ, Kang H. A case of eccrine angiomatous hamartoma in neurofibromatosis type-1 patient. Korean J Dermatol. 2006. 44:1339–1341.

14. Kwon YS, Lee KY, Kim DY, Park YK, Lee JH. A case of eccrine angiomatous hamartoma with unusual lipomatous involvement. Korean J Dermatol. 2008. 46:295–297.

15. Kim KH, Park HJ, Lee YS. A case of eccrine-pilar angiomatous hamartoma showing an unusual clinical manifestation. Korean J Dermatol. 1984. 22:549–552.

16. Kwon OC, Oh ST, Kim SW, Park GS, Cho BK. Eccrine angiomatous hamartoma. Int J Dermatol. 1998. 37:787–789.