Ann Dermatol.  2008 Dec;20(4):267-270. 10.5021/ad.2008.20.4.267.

A Case of Acantholytic Squamous Cell Carcinoma

Affiliations
  • 1Department of Dermatology, School of Medicine, Ewha Womans University, Seoul, Korea.
  • 2Department of Dermatology, Ilsan Paik Hospital, Inje University School of Medicine, Goyang, Korea.
  • 3Department of Dermatology, Seoul Paik Hospital, Inje University School of Medicine, Seoul, Korea.
  • 4Serion Dermatology Clinic, Seoul, Korea. skinewkk@ewha.ac.kr

Abstract

Acantholytic squamous cell carcinoma is a well-defined variant of squamous cell cancer in which significant portions of the neoplastic proliferation show a pseudoglandular or tubular microscopic pattern. It usually presents as a nodule with various colors, and it is accompanied by scaling, crusting, and ulceration on the sun-exposed areas of older aged individuals. Histologically, the tumor consists of a nodular, epidermal-derived proliferation that forms island-like structures. At least focally or sometimes extensively, the tumor cells shows a loss of cohesion within the central gland-like or tubular spaces. This tumor resembles the structure of eccrine neoplasms, but it is negative for dPAS, CEA and mucicarmine and it is only positive for EMA and cytokeratins. Herein we report a case of acantholytic squamous cell carcinoma that occurred on the face of an 82-year-old woman.

Keyword

Acantholytic; Adenoid; SCC; Skin

MeSH Terms

Adenoids
Aged
Aged, 80 and over
Carcinoma, Squamous Cell
Carmine
Humans
Keratins
Neoplasms, Squamous Cell
Skin
Ulcer
Carmine
Keratins
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