Gut Liver.  2015 May;9(3):424-429. 10.5009/gnl14072.

Concurrent Gastric and Pulmonary Mucosa-Associated Lymphoid Tissue Lymphomas with Pre-Existing Intrinsic Chronic Inflammation: A Case Report and a Review of the Literature

• Oh S
• Kim N
• Oh DH
• Bang SM
• Choi YJ
• Lee JY
• Lee KW
• Yoon HI
• Yang HC
• Paik JH
• Lee DH
• Jung HC

• KMID: 2155652
• DOI: http://doi.org/10.5009/gnl14072

Abstract

Herein, we report a rare case of concurrent gastric and pulmonary mucosa-associated lymphoid tissue (MALT) lymphomas. A 65-year-old man who had been diagnosed with Helicobacter pylori-positive gastric MALT lymphoma received eradication therapy and achieved complete remission. During follow-up, he developed de novo pulmonary MALT lymphoma as a sequela of pulmonary tuberculosis, accompanied by recurrent gastric MALT lymphoma. Polymerase chain reaction (PCR) products of the CDR3 region of the immunoglobulin heavy chain gene showed an overall polyclonal pattern with bands at 400 base pairs (bp) and 200 bp predominant in the pulmonary tissue, as well as two distinctive bands in the gastric tissue at 400 bp and 200 bp. This case suggests that multiorgan lymphomas are more likely to be independent from each other when they are far apart, involve different organ systems, and have independent precipitating factors.

Keyword

Stomach; Lung; Lymphoma, B-cell, marginal zone

MeSH Terms

Aged
Gastric Mucosa/pathology
Humans
Inflammation/pathology
Lung Neoplasms/etiology/*pathology
Lymphoma, B-Cell, Marginal Zone/etiology/*pathology
Male
Respiratory Mucosa/pathology
Stomach Neoplasms/etiology/*pathology
Tuberculosis, Pulmonary/complications