J Korean Med Sci.  2010 Jun;25(6):945-949. 10.3346/jkms.2010.25.6.945.

Congenital Acute Myeloid Leukemia with t(8;16) and t(17;19) Double Translocation: Case Presentation and Literature Review

• Sung TJ
• Lee DH
• Kim SK
• Jun YH

• KMID: 2150877
• DOI: http://doi.org/10.3346/jkms.2010.25.6.945

Abstract

Congenital leukemia is uncommon and excluding transient myeloproliferation associated with Down syndrome, makes up approximately 1% of childhood leukemias. A newborn boy was born with multiple subcutaneous nodules and large purpuric papules. Skin biopsy revealed proliferation of atypical hematologic cells in the dermis. Bone marrow morphology was consistent with acute myeloid leukemia (M5) and cytogenetic studies revealed t(8;16) and t(17;19) double translocation. Although prognosis of congenital leukemia is known to be dismal, recent reports showed spontaneous remissions. With the fear of chemotherapy-related toxicity, to treat or not to treat may be a dilemma both to parents and pediatricians. We report our experience and review the literature.

Keyword

Leukemia; Translocation, Genetic; Leukemic Infiltration; Drug Therapy

Figure

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  Fig. 1 Gross view of the skin. (A, B) There are widespread, scattered, yellowish-colored firm nodules with multiple purpuric macules and papules predominantly on the face and the trunk.

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