Immune Netw.  2011 Dec;11(6):336-341. 10.4110/in.2011.11.6.336.

T Cell Receptor Signaling That Regulates the Development of Intrathymic Natural Regulatory T Cells

• Song KD
• Hwang S
• Yun CH

• KMID: 2150717
• DOI: http://doi.org/10.4110/in.2011.11.6.336

Abstract

T cell receptor (TCR) signaling plays a critical role in T cell development, survival and differentiation. In the thymus, quantitative and/or qualitative differences in TCR signaling determine the fate of developing thymocytes and lead to positive and negative selection. Recently, it has been suggested that self-reactive T cells, escape from negative selection, should be suppressed in the periphery by regulatory T cells (Tregs) expressing Foxp3 transcription factor. Foxp3 is a master factor that is critical for not only development and survival but also suppressive activity of Treg. However, signals that determine Treg fate are not completely understood. The availability of mutant mice which harbor mutations in TCR signaling mediators will certainly allow to delineate signaling events that control intrathymic (natural) Treg (nTreg) development. Thus, we summarize the recent progress on the role of TCR signaling cascade components in nTreg development from the studies with murine model.

Keyword

T cell receptor; nTreg; Intrathymic selection

MeSH Terms

Animals
Mice
Receptors, Antigen, T-Cell
T-Lymphocytes
T-Lymphocytes, Regulatory
Thymocytes
Thymus Gland
Transcription Factors
United Nations
Receptors, Antigen, T-Cell
Transcription Factors

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