Korean J Vet Res.  2015 Dec;55(4):215-219. 10.14405/kjvr.2015.55.4.215.

Evaluations of vital signs and echocardiographic left ventricular function after the constant rate infusion of lidocaine and/or ketamine in Beagle dogs

• Kim YW
• Choi M
• Kim TJ
• Hyun C

• KMID: 2148063
• DOI: http://doi.org/10.14405/kjvr.2015.55.4.215

Abstract

Cardiopulmonary depression of long-term constant rate infusion (CRI) administration of multiple analgesic drugs is important, especially in critically ill dogs. Therefore, this study was conducted to evaluate the effects of lidocaine, ketamine or combined lidocaine-ketamine combination CRI treatment on vital signs and left ventricular (LV) function in healthy dogs. Six adult Beagle dogs were administered either ketamine (initial loading dose of 0.5 mg/kg followed by 10 microg/kg/min CRI), lidocaine (initial loading dose of 2 mg/kg followed by 0.025 mg/kg/min CRI), or combined lidocaine-ketamine intravenously. Arterial blood pressure (BP), heart rate (HR), respiratory rate (RR), body temperature (BT) and echocardiographic LV dimensions were measured before administration of medications, immediately after administration of drugs, and then every 10 min for 2 h. There were no significant changes in HR, RR, BT and BP after the administration of either lidocaine CRI, ketamine CRI, or combined lidocaine and ketamine CRI. There were also no significant changes in LV dimensions and stroke volume. The results revealed that treatment with either lidocaine, ketamine or combined lidocaine-ketamine may not cause cardiopulmonary suppression in healthy dogs.

Keyword

analgesia; cardiopulmonary; combination; constant rate infusion; dog

MeSH Terms

Adult
Analgesia
Analgesics
Animals
Arterial Pressure
Body Temperature
Critical Illness
Depression
Dogs*
Echocardiography*
Heart Rate
Humans
Ketamine*
Lidocaine*
Respiratory Rate
Stroke Volume
Ventricular Function, Left*
Vital Signs*
Analgesics
Ketamine
Lidocaine