Allergy Asthma Immunol Res.  2015 Sep;7(5):431-439. 10.4168/aair.2015.7.5.431.

Challenges in the Management of Asthma in the Elderly

Affiliations
  • 1Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea. shcho@snu.ac.kr
  • 2Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Center, Seoul, Korea.

Abstract

Recent literature has emphasized the clinical and socio-epidemiological significance of asthma in the elderly. However, why the disease burden remains high in this group is unclear. Elderly subjects usually have multiple chronic illnesses, and the role played by comorbidities in the context of asthma has been underappreciated. This review aims to summarize the literature associations between comorbidities and asthma in elderly patients. In addition, we discuss patient management issues.

Keyword

Asthma; elderly; comorbidity; management

MeSH Terms

Aged*
Asthma*
Chronic Disease
Comorbidity
Humans

Figure

  • Fig. 1 Schematic presentation for the epidemiology of asthma in the elderly. Lines indicate the aged-related changes in the prevalence; gray line, childhood-onset asthma; blue line, airway hyperresponsiveness; and red line, late-onset adult asthma. Adult asthma prevalence was depicted based on previous publications.2531 AHR, airway hyperresponsiveness; SE-IgE, staphylococcal enterotoxin IgE.

  • Fig. 2 Management issues of asthma in the elderly. Arrows with lines indicate the hypothetical relationships between aging, asthma, comorbidity, and other issues. Red line, effects of comorbidity; blue line, effects of aging-related changes; and dotted black line, effects of other management issues.


Cited by  11 articles

Impact of cognitive impairment on asthma control in older asthmatics
Gyu-Young Hur, Young-Min Ye, So Young Moon, Joo-Hee Kim, Ki-Suck Jung, Hae-Sim Park
Allergy Asthma Respir Dis. 2017;5(1):34-40.    doi: 10.4168/aard.2017.5.1.34.

Asia Pacific Allergy: it's been five years!
Yoon-Seok Chang
Asia Pac Allergy. 2016;6(1):1-2.    doi: 10.5415/apallergy.2016.6.1.1.

Pharmacotherapy in the management of asthma in the elderly: a review of clinical studies
Mi-Yeong Kim, Woo-Jung Song, Sang-Heon Cho
Asia Pac Allergy. 2016;6(1):3-15.    doi: 10.5415/apallergy.2016.6.1.3.

Respiratory allergies in the elderly: findings from the Korean Longitudinal Study on Health and Aging phase I study (2005–2006)
Woo-Jung Song, Yoon-Seok Chang
Asia Pac Allergy. 2017;7(4):185-192.    doi: 10.5415/apallergy.2017.7.4.185.

Time trends of the prevalence of allergic diseases in Korea: A systematic literature review
Sung-Yoon Kang, Woo-Jung Song, Sang-Heon Cho, Yoon-Seok Chang
Asia Pac Allergy. 2018;8(1):.    doi: 10.5415/apallergy.2018.8.e8.

Multifaceted interventions to reduce acute exacerbations in elderly asthmatics
So-Hee Lee, Woo-Jung Song, Heung-Woo Park, Min-Gyu Kang, Sae-Hoon Kim, Hye-Kyung Park, Sang-Heon Kim, Yong-Eun Kwon, Tae-Bum Kim, Byung-Jae Lee, Young-Koo Jee, Byung-Whui Choi, Sang-Heon Cho, Sun-Sin Kim
Asia Pac Allergy. 2018;8(1):.    doi: 10.5415/apallergy.2018.8.e1.

Risk Factors for Acute Exacerbations in Elderly Asthma: What Makes Asthma in Older Adults Distinctive?
Kyoung-Hee Sohn, Woo-Jung Song, Jong-Sook Park, Heung-Woo Park, Tae-Bum Kim, Choon-Sik Park, Sang-Heon Cho,
Allergy Asthma Immunol Res. 2020;12(3):443-453.    doi: 10.4168/aair.2020.12.3.443.

Efficacy and Safety of a Pressurized Metered-Dose Inhaler in Older Asthmatics: Comparison to a Dry Powder Inhaler in a 12-Week Randomized Trial
Seong-Dae Woo, Young-Min Ye, Youngsoo Lee, So-Hee Lee, Yoo Seob Shin, Joo Hun Park, Hyunna Choi, Hyun-Young Lee, Hyun-Jung Shin, Hae-Sim Park
Allergy Asthma Immunol Res. 2020;12(3):454-466.    doi: 10.4168/aair.2020.12.3.454.

Plasma LTE4/PGF Ratio and Blood Eosinophil Count Are Increased in Elderly Asthmatics With Previous Asthma Exacerbation
Ga-Young Ban, Young-Min Ye, Sang-Ha Kim, Gyu-Young Hur, Joo-Hee Kim, Jae-Jung Shim, Kumsun Cho, Joo-Youn Cho, Hae-Sim Park,
Allergy Asthma Immunol Res. 2017;9(4):378-382.    doi: 10.4168/aair.2017.9.4.378.

Serum micronutrients levels and clinical features of elderly asthmatics
So-Hee Lee, Woo-Jung Song, Heung-Woo Park, Sae-Hoon Kim, Hye-Kyung Park, Sang-Heon Kim, Yong Eun Kwon, Tae-Bum Kim, Byung-Jae Lee, Young-Koo Jee, Byoung Whui Choi, Sang-Heon Cho, Sun Sin Kim
Allergy Asthma Respir Dis. 2017;5(4):223-227.    doi: 10.4168/aard.2017.5.4.223.

A Delphi approach to the development of standard questionnaire to investigate asthma in Koreans
Jaewoo An, Kyung Suk Lee, Jin Tack Kim, Hyeon-Jong Yang, You Sook Cho, Kwang Cheon Jang, Woo-Jung Song, Hyouk-Soo Kwon, Jong Seo Yoon, Man Yong Han
Allergy Asthma Respir Dis. 2018;6(1):34-40.    doi: 10.4168/aard.2018.6.1.34.


Reference

1. Kinsella K, He W. An aging world: 2008. International Population Reports. Washington, D.C.: U.S. Government Printing Office;2009.
2. Yáñez A, Cho SH, Soriano JB, Rosenwasser LJ, Rodrigo GJ, Rabe KF, et al. Asthma in the elderly: what we know and what we have yet to know. World Allergy Organ J. 2014; 7:8.
3. Tsai CL, Lee WY, Hanania NA, Camargo CA Jr. Age-related differences in clinical outcomes for acute asthma in the United States, 2006-2008. J Allergy Clin Immunol. 2012; 129:1252–1258.e1.
4. Bahadori K, Doyle-Waters MM, Marra C, Lynd L, Alasaly K, Swiston J, et al. Economic burden of asthma: a systematic review. BMC Pulm Med. 2009; 9:24.
5. Parameswaran K, Hildreth AJ, Chadha D, Keaney NP, Taylor IK, Bansal SK. Asthma in the elderly: underperceived, underdiagnosed and undertreated; a community survey. Respir Med. 1998; 92:573–577.
6. Bellia V, Battaglia S, Catalano F, Scichilone N, Incalzi RA, Imperiale C, et al. Aging and disability affect misdiagnosis of COPD in elderly asthmatics: the SARA study. Chest. 2003; 123:1066–1072.
7. Enright PL, Kronmal RA, Higgins MW, Schenker MB, Haponik EF. Prevalence and correlates of respiratory symptoms and disease in the elderly. Cardiovascular Health Study. Chest. 1994; 106:827–834.
8. Lee JA, L Reed P, Berg JP. Asthma characteristics among older adults: using the California health interview survey to examine asthma incidence, morbidity and ethnic differences. J Asthma. 2014; 51:399–404.
9. Gillman A, Douglass JA. Asthma in the elderly. Asia Pac Allergy. 2012; 2:101–108.
10. Song WJ, Morice AH, Kim MH, Lee SE, Jo EJ, Lee SM, et al. Cough in the elderly population: relationships with multiple comorbidity. PLoS One. 2013; 8:e78081.
11. Patel MR, Janevic MR, Heeringa SG, Baptist AP, Clark NM. An examination of adverse asthma outcomes in U.S. Adults with multiple morbidities. Ann Am Thorac Soc. 2013; 10:426–431.
12. Aubas C, Bourdin A, Aubas P, Gamez AS, Halimi L, Vachier I, et al. Role of comorbid conditions in asthma hospitalizations in the south of France. Allergy. 2013; 68:637–643.
13. Steppuhn H, Langen U, Keil T, Scheidt-Nave C. Chronic disease comorbidity of asthma and unscheduled asthma care among adults: results of the national telephone health interview survey German Health Update (GEDA) 2009 and 2010. Prim Care Respir J. 2014; 23:22–29.
14. Sood A, Qualls C, Schuyler M, Arynchyn A, Alvarado JH, Smith LJ, et al. Adult-onset asthma becomes the dominant phenotype among women by age 40 years. The longitudinal CARDIA study. Ann Am Thorac Soc. 2013; 10:188–197.
15. Park HW, Kwon HS, Kim TB, Kim SH, Chang YS, Jang AS, et al. Differences between asthma in young and elderly: results from the COREA study. Respir Med. 2013; 107:1509–1514.
16. Park HW, Song WJ, Kim SH, Park HK, Kim SH, Kwon YE, et al. Classification and implementation of asthma phenotypes in elderly patients. Ann Allergy Asthma Immunol. 2015; 114:18–22.
17. Inoue H, Niimi A, Takeda T, Matsumoto H, Ito I, Matsuoka H, et al. Pathophysiological characteristics of asthma in the elderly: a comprehensive study. Ann Allergy Asthma Immunol. 2014; 113:527–533.
18. Ducharme ME, Prince P, Hassan N, Nair P, Boulet LP. Expiratory flows and airway inflammation in elderly asthmatic patients. Respir Med. 2011; 105:1284–1289.
19. Slavin RG, Haselkorn T, Lee JH, Zheng B, Deniz Y, Wenzel SE, et al. Asthma in older adults: observations from the epidemiology and natural history of asthma: outcomes and treatment regimens (TENOR) study. Ann Allergy Asthma Immunol. 2006; 96:406–414.
20. Kim S, Kim J, Kim K, Kim Y, Park Y, Baek S, et al. Healthcare use and prescription patterns associated with adult asthma in Korea: analysis of the NHI claims database. Allergy. 2013; 68:1435–1442.
21. Song WJ, Kang MG, Chang YS, Cho SH. Epidemiology of adult asthma in Asia: toward a better understanding. Asia Pac Allergy. 2014; 4:75–85.
22. Bauer BA, Reed CE, Yunginger JW, Wollan PC, Silverstein MD. Incidence and outcomes of asthma in the elderly. A population-based study in Rochester, Minnesota. Chest. 1997; 111:303–310.
23. Leone N, Courbon D, Berr C, Barberger-Gateau P, Tzourio C, Alpérovitch A, et al. Abdominal obesity and late-onset asthma: crosssectional and longitudinal results: the 3C study. Obesity (Silver Spring). 2012; 20:628–635.
24. Choy DK, Hui DS, Li ST, Ko FW, Ho S, Woo J, et al. Prevalence of wheeze, bronchial hyper-responsiveness and asthma in the elderly Chinese. Clin Exp Allergy. 2002; 32:702–707.
25. Kim YK, Kim SH, Tak YJ, Jee YK, Lee BJ, Kim SH, et al. High prevalence of current asthma and active smoking effect among the elderly. Clin Exp Allergy. 2002; 32:1706–1712.
26. Song WJ, Kim MY, Jo EJ, Kim MH, Kim TH, Kim SH, et al. Rhinitis in a community elderly population: relationships with age, atopy, and asthma. Ann Allergy Asthma Immunol. 2013; 111:347–351.
27. Pite H, Pereira AM, Morais-Almeida M, Nunes C, Bousquet J, Fonseca JA. Prevalence of asthma and its association with rhinitis in the elderly. Respir Med. 2014; 108:1117–1126.
28. Song WJ, Kim SH, Lim S, Park YJ, Kim MH, Lee SM, et al. Association between obesity and asthma in the elderly population: potential roles of abdominal subcutaneous adiposity and sarcopenia. Ann Allergy Asthma Immunol. 2012; 109:243–248.
29. Hopp RJ, Bewtra A, Nair NM, Townley RG. The effect of age on methacholine response. J Allergy Clin Immunol. 1985; 76:609–613.
30. O'Connor GT, Sparrow D, Weiss ST. A prospective longitudinal study of methacholine airway responsiveness as a predictor of pulmonary-function decline: the Normative Aging Study. Am J Respir Crit Care Med. 1995; 152:87–92.
31. Song WJ, Chang YS, Lim MK, Yun EH, Kim SH, Kang HR, et al. Staphylococcal enterotoxin sensitization in a community-based population: a potential role in adult-onset asthma. Clin Exp Allergy. 2014; 44:553–562.
32. Tomassen P, Jarvis D, Newson R, Van Ree R, Forsberg B, Howarth P, et al. Staphylococcus aureus enterotoxin-specific IgE is associated with asthma in the general population: a GA(2)LEN study. Allergy. 2013; 68:1289–1297.
33. Shaaban R, Zureik M, Soussan D, Neukirch C, Heinrich J, Sunyer J, et al. Rhinitis and onset of asthma: a longitudinal population-based study. Lancet. 2008; 372:1049–1057.
34. Jarvis D, Newson R, Lotvall J, Hastan D, Tomassen P, Keil T, et al. Asthma in adults and its association with chronic rhinosinusitis: the GA2LEN survey in Europe. Allergy. 2012; 67:91–98.
35. Song WJ, Jo EJ, Lee JW, Kang HR, Cho SH, Min KU, et al. Staphylococcal enterotoxin specific IgE and asthma: a systematic review and meta-analysis. Asia Pac Allergy. 2013; 3:120–126.
36. Leynaert B, Sunyer J, Garcia-Esteban R, Svanes C, Jarvis D, Cerveri I, et al. Gender differences in prevalence, diagnosis and incidence of allergic and non-allergic asthma: a population-based cohort. Thorax. 2012; 67:625–631.
37. Romieu I, Fabre A, Fournier A, Kauffmann F, Varraso R, Mesrine S, et al. Postmenopausal hormone therapy and asthma onset in the E3N cohort. Thorax. 2010; 65:292–297.
38. Beuther DA, Sutherland ER. Overweight, obesity, and incident asthma: a meta-analysis of prospective epidemiologic studies. Am J Respir Crit Care Med. 2007; 175:661–666.
39. McLeish AC, Zvolensky MJ. Asthma and cigarette smoking: a review of the empirical literature. J Asthma. 2010; 47:345–361.
40. Coogan PF, Castro-Webb N, Yu J, O'Connor GT, Palmer JR, Rosenberg L. Active and passive smoking and the incidence of asthma in the Black Women's Health Study. Am J Respir Crit Care Med. 2015; 191:168–176.
41. Polosa R, Knoke JD, Russo C, Piccillo G, Caponnetto P, Sarvà M, et al. Cigarette smoking is associated with a greater risk of incident asthma in allergic rhinitis. J Allergy Clin Immunol. 2008; 121:1428–1434.
42. Verbeken EK, Cauberghs M, Mertens I, Clement J, Lauweryns JM, Van de Woestijne KP. The senile lung. Comparison with normal and emphysematous lungs. 2. Functional aspects. Chest. 1992; 101:800–809.
43. Ware JH, Dockery DW, Louis TA, Xu XP, Ferris BG Jr, Speizer FE. Longitudinal and cross-sectional estimates of pulmonary function decline in never-smoking adults. Am J Epidemiol. 1990; 132:685–700.
44. James AL, Palmer LJ, Kicic E, Maxwell PS, Lagan SE, Ryan GF, et al. Decline in lung function in the Busselton Health Study: the effects of asthma and cigarette smoking. Am J Respir Crit Care Med. 2005; 171:109–114.
45. Enright PL, Burchette RJ, Peters JA, Lebowitz MD, McDonnell WF, Abbey DE. Peak flow lability: association with asthma and spirometry in an older cohort. Chest. 1997; 112:895–901.
46. Bellia V, Cuttitta G, Cibella F, Vignola AM, Crescimanno G, D'Accardi P, et al. Effect of ageing on peak expiratory flow variability and nocturnal exacerbations in bronchial asthma. Eur Respir J. 1997; 10:1803–1808.
47. Wardzyńska A, Kubsik B, Kowalski ML. Comorbidities in elderly patients with asthma: association with control of the disease and concomitant treatment. Geriatr Gerontol Int. 2014; Forthcoming.
48. Park J, Kim TB, Joo H, Lee JS, Lee SD, Oh YM. Diseases concomitant with asthma in middle-aged and elderly subjects in Korea: a population-based study. Allergy Asthma Immunol Res. 2013; 5:16–25.
49. Di Marco F, Santus P, Centanni S. Anxiety and depression in asthma. Curr Opin Pulm Med. 2011; 17:39–44.
50. Scott KM, Von Korff M, Ormel J, Zhang MY, Bruffaerts R, Alonso J, et al. Mental disorders among adults with asthma: results from the World Mental Health Survey. Gen Hosp Psychiatry. 2007; 29:123–133.
51. Niti M, Ng TP, Kua EH, Ho RC, Tan CH. Depression and chronic medical illnesses in Asian older adults: the role of subjective health and functional status. Int J Geriatr Psychiatry. 2007; 22:1087–1094.
52. Jiang M, Qin P, Yang X. Comorbidity between depression and asthma via immune-inflammatory pathways: a meta-analysis. J Affect Disord. 2014; 166:22–29.
53. Adams RJ, Wilson DH, Taylor AW, Daly A, Tursan d'Espaignet E, Dal Grande E, et al. Coexistent chronic conditions and asthma quality of life: a population-based study. Chest. 2006; 129:285–291.
54. Roberts NJ, Lewsey JD, Gillies M, Briggs AH, Belozeroff V, Globe DR, et al. Time trends in 30 day case-fatality following hospitalisation for asthma in adults in Scotland: a retrospective cohort study from 1981 to 2009. Respir Med. 2013; 107:1172–1177.
55. Moore WC, Bleecker ER, Curran-Everett D, Erzurum SC, Ameredes BT, Bacharier L, et al. Characterization of the severe asthma phenotype by the National Heart, Lung, and Blood Institute's Severe Asthma Research Program. J Allergy Clin Immunol. 2007; 119:405–413.
56. Moore WC, Meyers DA, Wenzel SE, Teague WG, Li H, Li X, et al. Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program. Am J Respir Crit Care Med. 2010; 181:315–323.
57. Amelink M, de Groot JC, de Nijs SB, Lutter R, Zwinderman AH, Sterk PJ, et al. Severe adult-onset asthma: A distinct phenotype. J Allergy Clin Immunol. 2013; 132:336–341.
58. Bachert C, van Steen K, Zhang N, Holtappels G, Cattaert T, Maus B, et al. Specific IgE against Staphylococcus aureus enterotoxins: an independent risk factor for asthma. J Allergy Clin Immunol. 2012; 130:376–381.e8.
59. Sutherland ER, Goleva E, Strand M, Beuther DA, Leung DY. Body mass and glucocorticoid response in asthma. Am J Respir Crit Care Med. 2008; 178:682–687.
60. Haldar P, Pavord ID, Shaw DE, Berry MA, Thomas M, Brightling CE, et al. Cluster analysis and clinical asthma phenotypes. Am J Respir Crit Care Med. 2008; 178:218–224.
61. Sutherland ER, Goleva E, King TS, Lehman E, Stevens AD, Jackson LP, et al. Cluster analysis of obesity and asthma phenotypes. PLoS One. 2012; 7:e36631.
62. Moreira A, Bonini M, Garcia-Larsen V, Bonini S, Del Giacco SR, Agache I, et al. Weight loss interventions in asthma: EAACI evidence-based clinical practice guideline (part I). Allergy. 2013; 68:425–439.
63. Kim SH, Sutherland ER, Gelfand EW. Is there a link between obesity and asthma? Allergy Asthma Immunol Res. 2014; 6:189–195.
64. Shah R, Yang Y. Health and economic burden of obesity in elderly individuals with asthma in the United States. Popul Health Manag. 2014; Forthcoming.
65. Kim TB, Jang AS, Kwon HS, Park JS, Chang YS, Cho SH, et al. Identification of asthma clusters in two independent Korean adult asthma cohorts. Eur Respir J. 2013; 41:1308–1314.
66. Polosa R, Thomson NC. Smoking and asthma: dangerous liaisons. Eur Respir J. 2013; 41:716–726.
67. de Marco R, Pesce G, Marcon A, Accordini S, Antonicelli L, Bugiani M, et al. The coexistence of asthma and chronic obstructive pulmonary disease (COPD): prevalence and risk factors in young, middle-aged and elderly people from the general population. PLoS One. 2013; 8:e62985.
68. Zeki AA, Schivo M, Chan A, Albertson TE, Louie S. The asthmaCOPD overlap syndrome: a common clinical problem in the elderly. J Allergy (Cairo). 2011; 2011:861926.
69. Soriano JB, Davis KJ, Coleman B, Visick G, Mannino D, Pride NB. The proportional Venn diagram of obstructive lung disease: two approximations from the United States and the United Kingdom. Chest. 2003; 124:474–481.
70. Milanese M, Di Marco F, Corsico AG, Rolla G, Sposato B, Chieco-Bianchi F, et al. Asthma control in elderly asthmatics. An Italian observational study. Respir Med. 2014; 108:1091–1099.
71. Menezes AM, Montes de, Pérez-Padilla R, Nadeau G, Wehrmeister FC, Lopez-Varela MV, et al. Increased risk of exacerbation and hospitalization in subjects with an overlap phenotype: COPD-asthma. Chest. 2014; 145:297–304.
72. Smith A, Krishnan JA, Bilderback A, Riekert KA, Rand CS, Bartlett SJ. Depressive symptoms and adherence to asthma therapy after hospital discharge. Chest. 2006; 130:1034–1038.
73. Park HW, Kim TW, Song WJ, Kim SH, Park HK, Kim SH, et al. Prediction of asthma exacerbations in elderly adults: results of a 1-year prospective study. J Am Geriatr Soc. 2013; 61:1631–1632.
74. Krauskopf KA, Sofianou A, Goel MS, Wolf MS, Wilson EA, Martynenko ME, et al. Depressive symptoms, low adherence, and poor asthma outcomes in the elderly. J Asthma. 2013; 50:260–266.
75. Bellia V, Pedone C, Catalano F, Zito A, Davì E, Palange S, et al. Asthma in the elderly: mortality rate and associated risk factors for mortality. Chest. 2007; 132:1175–1182.
76. Gibson PG, McDonald VM, Marks GB. Asthma in older adults. Lancet. 2010; 376:803–813.
77. Teodorescu M, Polomis DA, Gangnon RE, Fedie JE, Consens FB, Chervin RD, et al. Asthma control and its relationship with obstructive sleep apnea (OSA) in older adults. Sleep Disord. 2013; 2013:251567.
78. Hwang EK, Jin HJ, Nam YH, Shin YS, Ye YM, Nahm DH, et al. The predictors of poorly controlled asthma in elderly. Allergy Asthma Immunol Res. 2012; 4:270–276.
79. Lohia S, Schlosser RJ, Soler ZM. Impact of intranasal corticosteroids on asthma outcomes in allergic rhinitis: a meta-analysis. Allergy. 2013; 68:569–579.
80. American Lung Association-Asthma Clinical Research Centers' Writing Committee. Dixon AE, Castro M, Cohen RI, Gerald LB, Holbrook JT, et al. Efficacy of nasal mometasone for the treatment of chronic sinonasal disease in patients with inadequately controlled asthma. J Allergy Clin Immunol. 2014; Forthcoming.
81. Vashishta R, Soler ZM, Nguyen SA, Schlosser RJ. A systematic review and meta-analysis of asthma outcomes following endoscopic sinus surgery for chronic rhinosinusitis. Int Forum Allergy Rhinol. 2013; 3:788–794.
82. Gevaert P, Calus L, Van Zele T, Blomme K, De Ruyck N, Bauters W, et al. Omalizumab is effective in allergic and nonallergic patients with nasal polyps and asthma. J Allergy Clin Immunol. 2013; 131:110–116.e1.
83. Stenius-Aarniala B, Poussa T, Kvarnström J, Grönlund EL, Ylikahri M, Mustajoki P. Immediate and long term effects of weight reduction in obese people with asthma: randomised controlled study. BMJ. 2000; 320:827–832.
84. Dias-Júnior SA, Reis M, de Carvalho-Pinto RM, Stelmach R, Halpern A, Cukier A. Effects of weight loss on asthma control in obese patients with severe asthma. Eur Respir J. 2014; 43:1368–1377.
85. Chaudhuri R, Livingston E, McMahon AD, Lafferty J, Fraser I, Spears M, et al. Effects of smoking cessation on lung function and airway inflammation in smokers with asthma. Am J Respir Crit Care Med. 2006; 174:127–133.
86. Tønnesen P, Pisinger C, Hvidberg S, Wennike P, Bremann L, Westin A, et al. Effects of smoking cessation and reduction in asthmatics. Nicotine Tob Res. 2005; 7:139–148.
87. Baraniak A, Sheffield D. The efficacy of psychologically based interventions to improve anxiety, depression and quality of life in COPD: a systematic review and meta-analysis. Patient Educ Couns. 2011; 83:29–36.
88. Yorke J, Fleming SL, Shuldham CM. Psychological interventions for adults with asthma. Cochrane Database Syst Rev. 2006; CD002982.
89. Matsunaga K, Yamagata T, Minakata Y, Ichinose M. Importance of assistance by caregivers for inhaled corticosteroid therapy in elderly patients with asthma. J Am Geriatr Soc. 2006; 54:1626–1627.
90. Baptist AP, Talreja N, Clark NM. Asthma education for older adults: results from the National Asthma Survey. J Asthma. 2011; 48:133–138.
91. Sofianou A, Martynenko M, Wolf MS, Wisnivesky JP, Krauskopf K, Wilson EA, et al. Asthma beliefs are associated with medication adherence in older asthmatics. J Gen Intern Med. 2013; 28:67–73.
92. Federman AD, Wolf M, Sofianou A, Wilson EA, Martynenko M, Halm EA, et al. The association of health literacy with illness and medication beliefs among older adults with asthma. Patient Educ Couns. 2013; 92:273–278.
93. Federman AD, Wolf MS, Sofianou A, Martynenko M, O'Connor R, Halm EA, et al. Self-management behaviors in older adults with asthma: associations with health literacy. J Am Geriatr Soc. 2014; 62:872–879.
94. O'Conor R, Wolf MS, Smith SG, Martynenko M, Vicencio DP, Sano M, et al. Health literacy, cognitive function, proper use and adherence to inhaled asthma controller medications among older adults with asthma. Chest. 2014; Forthcoming.
95. Baptist AP, Ross JA, Yang Y, Song PX, Clark NM. A randomized controlled trial of a self-regulation intervention for older adults with asthma. J Am Geriatr Soc. 2013; 61:747–753.
96. Hong JS, Kang HC, Kim J. Continuity of care for elderly patients with diabetes mellitus, hypertension, asthma, and chronic obstructive pulmonary disease in Korea. J Korean Med Sci. 2010; 25:1259–1271.
97. Park SY, Yoon SY, Shin B, Kwon HS, Kim TB, Moon HB, et al. Clinical factors affecting discrepant correlation between asthma control test score and pulmonary function. Allergy Asthma Immunol Res. 2015; 7:83–87.
98. Sim DW, Choi IS, Kim SH. Suppressive effects of long-term treatment with inhaled steroids on hypothalamic-pituitary-adrenal axis in asthma. Allergy Asthma Respir Dis. 2014; 2:285–292.
99. Park HW. The role of tiotropium in the management of asthma. Asia Pac Allergy. 2012; 2:109–114.
100. Creticos P, Knobil K, Edwards LD, Rickard KA, Dorinsky P. Loss of response to treatment with leukotriene receptor antagonists but not inhaled corticosteroids in patients over 50 years of age. Ann Allergy Asthma Immunol. 2002; 88:401–409.
Full Text Links
  • AAIR
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr