Allergy Asthma Immunol Res.  2015 Sep;7(5):421-430. 10.4168/aair.2015.7.5.421.

Chronic Rhinosinusitis and the Coagulation System

Affiliations
  • 1Division of Allergy and Immunology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA. rpschleimer@northwestern.edu
  • 2Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University College of Medicine, Seoul, Korea.
  • 3Division of Rheumatology, Department of Medicine, Kyung Hee University School of Medicine, Seoul, Korea.
  • 4Division of Otorhinolaryngology Head and Neck Surgery, Department of Sensory and Locomotor Medicine, University of Fukui, Fukui, Japan.

Abstract

Chronic rhinosinusitis (CRS) is one of the most common chronic diseases in adults and severely affects quality of life in patients. Although various etiologic and pathogenic mechanisms of CRS have been proposed, the causes of CRS remain uncertain. Abnormalities in the coagulation cascade may play an etiologic role in many diseases, such as asthma and other inflammatory conditions. While studies on the relationship between asthma and dysregulated coagulation have been reported, the role of the coagulation system in the pathogenesis of CRS has only been considered following recent reports. Excessive fibrin deposition is seen in nasal polyp (NP) tissue from patients with chronic rhinosinusitis with nasal polyp (CRSwNP) and is associated with activation of thrombin, reduction of tissue plasminogen activator (t-PA) and upregulation of coagulation factor XIII-A (FXIII-A), all events that can contribute to fibrin deposition and crosslinking. These findings were reproduced in a murine model of NP that was recently established. Elucidation of the mechanisms of fibrin deposition may enhance our understanding of tissue remodeling in the pathophysiology of NP and provide new targets for the treatment of CRSwNP.

Keyword

Rhinosinusitis; nasal polyps; coagulation; fibrinolysis; tissue plasminogen activator; factor XIIIa

MeSH Terms

Adult
Asthma
Blood Coagulation Factors
Chronic Disease
Factor XIIIa
Fibrin
Fibrinolysis
Humans
Nasal Polyps
Quality of Life
Thrombin
Tissue Plasminogen Activator
Up-Regulation
Blood Coagulation Factors
Factor XIIIa
Fibrin
Thrombin
Tissue Plasminogen Activator
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