The Effect of Topical Perfluorophenanthrene on Corneal Neovascularization in the Rats

Cho, Ho Kyun; Chung, Tae Bum

Abstract

The effect of topical perfluorophenanthrene on corneal neovascularization was studied at chemically induced corneal burn on the rats. A central corneal burn was produced with 10% NaOH. Right eye was treated with perfluorophenanthrene and gentamicin eye drops four times a day for five days, the left with balanced salt solution and gentamicin eye drops as control. After five days treatment the rats were sacrified, and the tissue slide were prepared for microscopIc examination. Using slide projector the tissue slide were projected and magnified on the screen. The number of corneal new vessels, the distance of new vessel from the limbus, and the degree of increased corneal thickness were calculated in both groups. As the result there were no statistical difference between two groups. Analysis using ANOVA program showed the fact that statistically significant correlationship between the degree of corneal thickness and the number of the new vessels and the distance from the limbus were found. The result could confirm the mechanism of corneal neovascularization that disarrangement of the compact corneal tissue could allow the formation of the new vessels.