J Korean Ophthalmol Soc.
1996 Sep;37(9):1413-1421.
Antiangiogenic Effects of Retinoids on Corneal Neovascularization
- Affiliations
-
- 1Department of Ophthalmology, College of Medicine, Seoul National University, Seoul, Korea.
Abstract
- We investigated the effect of topical application of retimids on the corneal neovascularization in the rat induced by chemical cauterization. The center of corneas of Wistar rats were Cauterized with a silver/potassium nitrate applicator for 5 seconds. And then they were treated topically with 0.1%, 0.2%, 0.5%, 2.0% all-trans retimids (retinol, retinoic acid, retinaldehyde) and dimethyl sulfoxide as a control four times a day. After appiications of eye drops for 5 days, each rat was kined and then perfused with a mixture of 11% gelatin 10% India ink-lactated Ringer's solution. Corneal flat preparation were made, and then the percent of the corneal area occupied by blood vessels were analized by computerized image analyzer. Percent vascularization of 0.1% and 0.2% retnoids were not significantly different from control group(p>0.05). Percent vascu1arization of 0.5% retinaldehyde and all 2.0% retnoids were significantly lower than the contml group(p>0.5). These naturally occurring retinoids were effective in antiarlgiogenesis of rat cornea at relatively high concentrations (>0.5%), when treated topicany, It will be necessary to further study on more potent antiangiogenic, at lower concentration, synthetic retimids for the treatment of angiogenic diseases.
Keyword
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- The Effect of Cartilage on Corneal Neovascularization
- Treatment of corneal neovascularization with argon laser
- Inhibition of corneal neovascularization by rapamycin
- The Effects of a Subtenoncapsular Injection of Bevacizumab for Ocular Surface Disease With Corneal Neovascularization
- Inhibitory Effect of Rapamycin on Corneal Neovascularization induced by Angiogenin in Rabbits
