J Korean Soc Neonatol.  2007 May;14(1):30-38.

Immediate Postnatal Serum Tumor Necrosis Factor-Alpha Concentration and the Development of Bronchopulmonary Dysplasia

• Lee JA
• Kim BI
• Lim IS
• Choi CW
• Kim EK
• Kim HS
• Choi JH

Abstract

PURPOSE: We tested the hypothesis that preterm infants who develop bronchopulmonary dysplasia (BPD) have higher concentration of serum tumor necrosis factor-alpha (TNF-alpha) within 8 hours after birth than those who do not.
METHODS
Serum and tracheal aspirate (TA) TNF-alpha concentrations were measured by enzyme-linked immunosorbent assay in the thirty-four preterm infants born before 32 weeks of gestation. Multiple logistic regression analysis was done.
RESULTS
Median concentrations of both serum and TA TNF-alpha were higher in BPD group than in non BPD group [serum TNF-alpha, 214.52 pg/mL (84.20-244.20) versus 100.07 pg/mL (78.43-225.52), P=0.037],[TA TNF-alpha, 13.12 pg/mL (10.43-64.67) versus 11.58 pg/ mL (9.76-58.53), P=0.038]. After making adjustments for the effects of gestational age at birth, 5 minute Apgar score less than 7 and histologic chorioamnionitis, only serum TNF-alpha concentration was independently significant [P=0.045 Odds ratio, 1.381 95% confidence interval, 1.007-1.895]. The diagnostic indices of TNF-alpha (cutoff, 97.1 pg/mL) as a predictor of development of BPD were: sensitivity of 85.7%, specificity of 38.5%, positive predictive value of 69.2%, negative predictive value of 62.5% (P=0.037).
CONCLUSION
Increased serum TNF-alpha concentration within 8 hours after birth may be a significant risk factor of later development of BPD.

Keyword

Bronchopulmonary dysplasia; Tumor necrosis factor-alpha; Risk factor

MeSH Terms

Apgar Score
Bronchopulmonary Dysplasia*
Chorioamnionitis
Enzyme-Linked Immunosorbent Assay
Female
Gestational Age
Humans
Infant, Newborn
Infant, Premature
Logistic Models
Odds Ratio
Parturition
Pregnancy
Risk Factors
Sensitivity and Specificity
Tumor Necrosis Factor-alpha*
Tumor Necrosis Factor-alpha