Korean J Helicobacter Up Gastrointest Res.  2011 Dec;11(3):161-164. 10.7704/kjhugr.2011.11.3.161.

Molecular Genetic Approach of Gastric MALT Lymphoma

• Kim M
• Kang CS

• KMID: 2143445
• DOI: http://doi.org/10.7704/kjhugr.2011.11.3.161

Abstract

Mucosa-associated lymphoid tissue (MALT) lymphoma is a common low grade B-cell lymphoma arising from a background of chronic inflammatory disease at a number of mucosal sites. The association between Helicobacter pylori and gastric MALT lymphoma is well known and it appears that H. pylori is critical for lymphomagenesis and also creates a microenvironment favoring the growth of neoplastic B cells. The understanding of MALT lymphoma biology has significantly improved, and at least 4 recurrent translocations t(11;18)/API2-MALT1, t(1;14)/IGH-BCL10, t(14;18)/IGH-MALT1 and t(3;14)/IGH-FOXP1 have been implicated in the pathogenesis of MALT lymphoma. Here, we review the recent advances in association of microorganisms with MALT lymphoma and the molecular genetics underlying the lymphoma development.

Keyword

Mucosa-associated lymphoid tissue lymphoma; Chromosomal translocation; Bacteria

MeSH Terms

B-Lymphocytes
Bacteria
Biology
Helicobacter pylori
Lymphoid Tissue
Lymphoma
Lymphoma, B-Cell
Lymphoma, B-Cell, Marginal Zone
Molecular Biology
Translocation, Genetic