Korean J Med.  1999 Apr;56(4):526-531.

A case of Synchronous Hepatocellular Carcinoma and Waldenstrom's Macroglobulinemia in Patient with Chronic Hepatitis C

• Kim HJ
• Lee JI
• Lim KW
• Kang SW
• Dong SH
• Kim HJ
• Kim BH
• Chang YW
• Yoon HJ
• Chang R

Abstract

Hepatocellular cell carcinoma (HCC) is one of the most common and malignant neoplasm in the world. Waldenstrom's macroglobulinemia (WM) is a rare B-lymphocyte neoplasia characterized by monoclonal production of IgM Igs and by a marrow containing a diffuse infiltrate of plasmocytoid lymphocytes. A 67-year-old man was admitted because of multiple site pain, especially right flank and posterior neck pain. Physical examination showed hepatomegaly. Laboratory findings were as follows; total protein 8.6 g/dL, albumin 3.1 g/dL with monoclomal protein(IgM-lamda). Hepatitis C virus(HCV) infection was detected by polymerase chain reaction(PCR). Computed tomography and celiac angiography disclosed HCC. Aspiration biopsy of the liver revealed HCC. Magnetic resonance imaging showed compression fracture and epidural mass in cervical spines. Bone marrow examination revealed normocellularity with an increase of lymphoplasmacytic series. He was diagnosed as having WM and HCC. HCC is frequently associated with other malignancies. As the site of the extrahepatic primary cancer, the stomach ranked first. WM is also known for its association with an increased incidence of a second neoplasm, most of which are less differentiated lymphomas. but an association with a non-lymphoreticular malignancy is quite rare. We report first case of synchronous HCC with bone metastasis and WM (IgM,lamdatype) in korean with chronic hepatitis C.

Keyword

Waldenstrom's macroglobulinemia; Hepatocellular cell carcinoma; Hepatitis C virus

MeSH Terms

Aged
Angiography
B-Lymphocytes
Biopsy, Needle
Bone Marrow
Bone Marrow Examination
Carcinoma, Hepatocellular*
Fractures, Compression
Hepacivirus
Hepatitis C
Hepatitis C, Chronic*
Hepatitis, Chronic*
Hepatomegaly
Humans
Immunoglobulin M
Incidence
Liver
Lymphocytes
Lymphoma
Magnetic Resonance Imaging
Neck Pain
Neoplasm Metastasis
Neoplasms, Second Primary
Physical Examination
Spine
Stomach
Waldenstrom Macroglobulinemia*
Immunoglobulin M