Korean J Med.  2001 Jul;61(1):50-52.

A case of propylthiouracil-induced hepatitis with agranulocytosis

• Lee JK
• Kim HJ
• Oh HE

Abstract

Hyperthyroidism is a common condition which is initially managed with an antithyroid drug, either propylthiouracil or methimazole. Adverse reactions occur in 1-5% of patients taking antithyroid medications, most commonly transient, benign leukopenia and skin rash. Agranulocytosis and liver dysfunction are reactions which occur infrequently. Severe hepatic toxicity combined with agranulocytosis has been known as rare complication. Experimental studies have demonstrated that immunological mechanisms play an important role. While most patients are completely recovered after stop of medication, some patients can show grave prognosis. We report a case of propylthiouracil induced hepatitis with agranulocytosis.

Keyword

Propylthiouracil; Agranulocytosis; Hepatitis

MeSH Terms

Agranulocytosis*
Exanthema
Hepatitis*
Humans
Hyperthyroidism
Leukopenia
Liver Diseases
Methimazole
Prognosis
Propylthiouracil
Methimazole
Propylthiouracil