Korean J Intern Med.
2005 Dec;20(4):335-338. 10.3904/kjim.2005.20.4.335.
Management of a Pregnant Patient with Graves' Disease Complicated by Propylthiouracil induced Agranulocytosis
- Affiliations
-
- 1Department of Internal Medicine, Catholic University of Daegu School of Medicine, Daegu, Korea. hdyoon@cu.ac.kr
- KMID: 1115259
- DOI: http://doi.org/10.3904/kjim.2005.20.4.335
Abstract
- Relapse and exacerbation of Graves' disease during pregnancy is rare, and thionamide induced agranulocytosis is an uncommon side effect. We report a case of a pregnant woman in her 24th week of gestation that experienced a relapse of Graves' disease that was complicated by propylthiouracil induced agranulocytosis. Following the discontinuation of propylthiouracil and administration of a broad-spectrum of antibiotics, agranulocytosis subsided within 10 days. A total thyroidectomy to avoid any future relapse was planned and a short course of a beta-adrenergic blocker and Lugol solution were prescribed before the operation. At the 28th week of gestation, a total thyroidectomy was performed without complications and thyroxine replacement therapy was commenced. At the 40th week of gestation, labor was induced and a 3, 370 g healthy male infant was born without clinical features of thyrotoxicosis. We report herein on the patient and the treatment options for this rare and complicated case.
Keyword
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Two Cases of Aplastic Anemia Following Propylthiouracil
- A Case of Transient Granulocytopenia during Treatment of a Patient with Graves' Disease and Type 1 Diabetes Mellitus - Differential Diagnosis from Agranulocytosis by a Single Injection of G-CSF
- Agranulocytosis due to secondary exposure to antithyroid drugs in a relapsed Graves' disease patient
- A Case of Methimazole-induced Agranulocytosis and Kikuchi's Disease in a Patient with Graves' Disease
- A case of propylthiouracil-induced hepatitis with agranulocytosis
