Korean J Nephrol.  2011 Nov;30(6):689-693.

Very-Late Onset Diffuse Large B-cell Lymphoma with CD3 Coexpression in a Kidney Transplant Patient

• Kim B
• Chung S
• Kang SH
• Cho SG
• Park CW
• Chang YS

Abstract

B-lineage non-Hodgkin lymphoma may aberrantly coexpress T-cell markers. In general population, however, cases of diffuse large B-cell lymphomas with CD3 co-expression are rare because the CD3 marker is the most lineage specific T-cell antigen. We report a case of CD3 coexpressed diffuse large B-cell lymphoma in a 47-year-old male patient presented with dyspepsia who had transplanted a kidney 17 years ago. An esophagogastroduodenoscopy displayed an ulcerated mass in the gastric antrum. The pathology of the mass was monomorphic post-transplant lymphoproliferative disorder - specifically, CD20- and CD3-positive diffuse large B-cell lymphoma. Resection of the mass and postop chemotherapy were performed. A follow-up computerized tomography showed disapperance of tumor. No recurrence was observed until 7 month after treatment. Nevertheless, the patient's renal function gradually aggrevated and progressed to end stage renal disease. As far as we know, this is the first case of diffuse large B-cell lymphoma with CD3 coexpression after kidney transplant.

Keyword

Neoplasm transplantation; Lymphoproliferative disorder; Diffuse large B-cell lymphoma

MeSH Terms

B-Lymphocytes
Dyspepsia
Endoscopy, Digestive System
Follow-Up Studies
Humans
Kidney
Kidney Failure, Chronic
Lymphoma, B-Cell
Lymphoma, Non-Hodgkin
Lymphoproliferative Disorders
Male
Middle Aged
Neoplasm Transplantation
Pyloric Antrum
Recurrence
T-Lymphocytes
Transplants
Ulcer