Korean J Blood Transfus.
2015 Apr;26(1):1-8. 10.17945/kjbt.2015.26.1.1.
Transfusion Strategy and Laboratory Update on the DEL Variant
- Affiliations
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- 1Department of Biomedical Sciences, Chonnam National University, Gwangju, Korea.
- 2Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. duck.cho@samsung.com
- 3The Division of Human Blood Safety Surveillance, Korea Centers for Disease Control and Prevention, Cheongwon, Korea.
- 4Department of Laboratory Medicine, Seoul National University Bundang Hospital, Seongnam, Korea. m91w95pf@snu.ac.kr
- KMID: 2139820
- DOI: http://doi.org/10.17945/kjbt.2015.26.1.1
Abstract
- Red cells that express extremely low levels of D antigen that cannot be detected by routine serologic tests are designated as DEL. Most DEL blood donors are typed as D-negative. However, DEL red blood cells can be recognized by serological adsorption and elution test or molecular RHD genotyping. Anti-D production in patients with D-negative who received transfusion containing DEL blood has reported, therefore distinction between DEL variant and true D- negative is clinically important. This review highlights a transfusion strategy and laboratory update on the DEL variant in the Korean population.
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