Korean J Blood Transfus.
2016 Aug;27(2):169-173. 10.17945/kjbt.2016.27.2.169.
A Case of Primary Anti-D Alloimmunization by RHD (c.1227G>A) DEL Red Blood Cell Transfusion
- Affiliations
-
- 1Department of Laboratory Medicine, Korea University Guro Hospital, Seoul, Korea. malarim@korea.ac.kr
- 2Blood Transfusion Research Institute, Korea Red Cross, Wonju, Korea.
- KMID: 2350673
- DOI: http://doi.org/10.17945/kjbt.2016.27.2.169
Abstract
- The Rh blood group D antigen is the most immunogenic of all antigens, next to ABO antigens. Anti-D immunization is clinically important since it may cause clinical problems, such as severe hemolytic transfusion reactions and hemolytic disease of the newborn. DEL is an extremely weak D variant that cannot be detected by basic serologic typing and is typed as D-negative without the absorption-elution techniques and RHD genotyping. Of the DEL phenotype, RHD (c.1227G>A) allelic variant is the most common in Korea. The DEL phenotype has been considered to carry only a few D antigens to induce anti-D immunization, but a few cases have reported that this allelic variant is capable of inducing anti-D immunization in a D-negative recipient, for which it is clinical significant. Herein, we present a case of primary anti-D alloimmunization in a RhD negative patient after receiving RHD (c.1227G>A) DEL red cell transfusion identified by serological and molecular tests, including RHD genotyping.
Keyword
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- A Patient with RhD(el) (1227G>A) Failed to Produce Detectable Anti-D after Transfusion of RhD Positive Red Blood Cells
- The Experience of RHD Genotyping in D-negative Blood Donors
- Primary anti-D Immunization by DEL Red Blood Cells
- Detection of RHD 1227G>A and 1222T>C Using PCR-Restriction Fragment Length Polymorphism
- Application of Multiplex Ligation-Dependent Probe Amplification Assay for Genotyping Major Blood Group Systems Including DEL Variants in the D-Negative Korean Population
