A Study on Serum and Urinary Biochemical Parameters and Chemical Compositions of Urinary Calculi

Lee, Moo Sang; Chung, Woo Sik

Abstract

This study was performed for clarifying whether chemical compositions of urinary calculi may be associated with serum and urinary biochemical parameters in 50 patients with urinary calculi. The following results were obtained. 1. The results of chemical analysis of 50 urinary calculi revealed calcium oxalate in 62%, calcium phosphate in 12%, calcium oxalate and phosphate in 12%, MAP (magnesium ammonium phosphate) in 6% and others including uric acid in 8%. The major component of urinary calculi was calcium oxalate. 2. Among the serum biochemical parameters, only the mean value of phosphorus was significantly lower in calcium stone group than in non calcium stone group. 3. Among the 24 hour urinary biochemical parameters, all (calcium, phosphorus, uric acid and magnesium) were higher in calcium stone group than in non calcium stone group, but these differences were not statistically significant. 4. Hypercalciuria (>200mg/day) was observed in 38% of lithiasis patients. The incidence of hypercalciuria was greater in calcium stone group (42%) than in non calcium stone group (14%). 5. Hyperuricosuria (>800mg/day in male, >750mg/day in female) was observed in 22% of lithiasis patients. The incidence of hyperuricosuria was greatest in calcium oxalate group (26%) if that of "others" group including uric acid stone (50%) was excluded. 6. The incidence of alkaline urinary pH(>7.0) in lithiasis patients was 44% and urinary pH in calcium phosphate and MAP stone group was more alkaline. 7. The chemical compositions of 10 staghorn stones showed calcium oxalate in 4 cases, MAP in 3 cases, calcium phosphate in 2 cases and other in 1 case.