Korean J Urol.  1992 Jun;33(3):418-423.

Chromosomal changes in transitional cell carcinoma of the bladder

• Park HJ
• Yoon DK

Abstract

The chromosome constitution of 11 superficial and 2 invasive transitional cell carcinomas of the bladder has been examined by culture technique. Of the 11 superficial tumors, 6 (54.5%) had the modal number ranging in the diploid area (40-49 chromosomes) and 5 of them (83.5%) had no recurrence for more than 1 year. Six (54.5%) out of 11 superficial tumors had 1 to 3 marker chromosomes and only 2 (33.3%) of them recurred but 1 (20%) out of remaining 5 (no marker chromosome) superficial bladder tumors has recurred. On the other hand. all invasive transitional cell carcinomas of the bladder had hyperdiploid modes and marker chromosomes. Although the numbers of subject for this study are small we speculate that a large number of chromosomes and presence of marker chromosome might be correlated with aggressiveness of a particular tumor diathesis but the meaning of marker chromosome should be reevaluated. So in order to get the prognostic information chromosomal analysis should be thought combined with other prognostic factors.

Keyword

transitional cell carcinoma; bladder; cytogenetic analysis

MeSH Terms

Carcinoma, Transitional Cell*
Constitution and Bylaws
Culture Techniques
Cytogenetic Analysis
Diploidy
Disease Susceptibility
Hand
Recurrence
Urinary Bladder Neoplasms
Urinary Bladder*