Nucl Med Mol Imaging.  2014 Mar;48(1):1-15.

Recent Trends in PET Image Interpretations Using Volumetric and Texture-based Quantification Methods in Nuclear Oncology

• Rahim MK
• Kim SE
• So H
• Kim HJ
• Cheon GJ
• Lee ES
• Kang KW
• Lee DS

Abstract

Image quantification studies in positron emission tomography/computed tomography (PET/CT) are of immense importance in the diagnosis and follow-up of variety of cancers. In this review we have described the current image quantification methodologies employed in 18F-fluorodeoxyglucose (18F-FDG) PET in major oncological conditions with particular emphasis on tumor heterogeneity studies. We have described various quantitative parameters being used in PET image analysis. The main contemporary methodology is to measure tumor metabolic activity; however, analysis of other image-related parameters is also increasing. Primarily, we have identified the existing role of tumor heterogeneity studies in major cancers using 18F-FDG PET. We have also described some newer radiopharmaceuticals other than 18F-FDG being studied/used in the management of these cancers. Tumor heterogeneity studies are being performed in almost all major oncological conditions using 18F-FDG PET. The role of these studies is very promising in the management of these conditions.

Keyword

Positron emission tomography; Quantification; Standard uptake value; Tumor heterogeneity studies; Textural analysis

MeSH Terms

Diagnosis
Electrons
Fluorodeoxyglucose F18
Population Characteristics
Positron-Emission Tomography
Radiopharmaceuticals
Fluorodeoxyglucose F18
Radiopharmaceuticals