Nutr Res Pract.  2008 Dec;2(4):247-251. 10.4162/nrp.2008.2.4.247.

Antioxidant and antidiabetic activities of extracts from Cirsium japonicum roots

• Yin J
• Heo SI
• Wang MH

• KMID: 2139199
• DOI: http://doi.org/10.4162/nrp.2008.2.4.247

Abstract

This study investigated the antioxidant activity of methanol (MeOH) and water extracts from roots of Cirsium japonicum in vitro. MeOH extract showed a stronger free radical scavenging activity than water extract. However, both of extracts showed a concentration dependent hydroxyl radical scavenging activity, reducing power and metal chelating ability. MeOH extract had greater phenolic and flavonoid contents than water extract. The antidiabetic activity of these two extracts was evaluated by the alpha-glucosidase inhibition assay. The water extract showed a considerable alpha-glucosidase inhibitory activity. To our knowledge, this may be the first time to report the antioxidant and antidiabetic activities in Cirsium japonicum roots.

Keyword

Cirsium japonicum; antioxidant; antidiabetic; methanol and water extracts

MeSH Terms

alpha-Glucosidases
Cirsium
Hydroxyl Radical
Methanol
Phenol
Water
Hydroxyl Radical
Methanol
Phenol
Water
alpha-Glucosidases

Figure

• 

  Fig. 1 Scavening effect on hydroxyl radical of methanol and water extracts from Cirsium japonicum roots. a-Tocopherol and BHT at the concentration of 100 µg/ml were used as the positive control. Data were presented as the mean ± SD (n=3). (□: water ext., ▒: MeOH ext.)

• 

  Fig. 2 Reducing power of methanol and water extracts from Cirsium japonicum roots. a-Tocopherol was used as the positive control. Data were presented as the mean ± SD (n=3). (□: water ext., ▒: MeOH ext., ■: a-tocopherol)

• 

  Fig. 3 Ferrous ions chelating ability of methanol and water extracts from Cirsium japonicum roots. EDTA at the concentration of 100 µg/ml was used as the positive control. Data were presented as the mean ± SD (n=3). (□: water ext., ■: MeOH ext.)

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