J Korean Neurol Assoc.
1993 Jun;11(2):181-186.
Long-Term Therapeutic Efficacy of Levodopa in Parkinson's Disease
- Affiliations
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- 1Department of Neurology, College of Medicine, Yonsei University, Korea.
Abstract
- We evaluated the therapeutic effects and complications of 118 patients with idiopathic parkisonism who were receiving levodopa therapy for more than 1 year. Response to therapy and complications of drug were correlated with duration of the disease and with duration of the treatment. Patients with motor fluctuation were likely to have been treated for 3 years or longer. Patients treated with levodopa for 5 years or longer were significantly more impaired with parkinsonism than patients treated for 1 to 3 years. Our findings suggest that the deterioration of responsiveness after several years of levododpa therapy may be due to the therapy itself, and utilization of levodopa therapy should be delayed until a patient becomes significantly impaired in occupational or social situations.
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