J Korean Med Assoc.  2006 Jun;49(6):475-485. 10.5124/jkma.2006.49.6.475.

What's New in Transplantation Surgery and Medicine

• Ahn HJ
• Kim SI
• Kim YS

• KMID: 2137827
• DOI: http://doi.org/10.5124/jkma.2006.49.6.475

Abstract

The field of organ transplantation has undergone a continual evolution to become the standard treatment for patients with end-stage diseases in diverse organs including the kidney, liver, pancreas, intestine, heart, and lung diseases. The efforts to increase organ donation and clinical studies along with basic researches are very important for the progress of transplantation medicine. This review is focused on "What's new in transplantation surgery and medicine", addressing the current hot issues on the attempts at organ shortage, recent findings on antigen recognition, improved immunosuppressive strategies, and finally recent advancements in kidney and liver transplantation.

Keyword

Transplantation; Recent advancement

MeSH Terms

Heart
Humans
Intestines
Kidney
Liver
Liver Transplantation
Lung Diseases
Organ Transplantation
Pancreas
Tissue and Organ Procurement
Transplantation
Transplants

Reference

1. Cecka JM. Cecka JM, Terasaki PI, editors. The OPTN/UNOS Renal Transplant Registry. Los Angeles Clinical Transplants 2004. 2005. UCLA Immunogenetics Center;1–5.

2. Lorenz M, Regele H, Schillinger M, Kletzmayr J, Haidbauer B, Bohmig GA, et al. Peritransplant immunoadsorption: a strategy enabling transplantation in highly sensitized crossmatch-positive cadaveric kidney allograft recipients. Transplantation. 2005. 79:696–701.

3. Zachary AA, Montgomery RA, Ratner LE, Samaniego-Picota M, Haas M, Leffell MS, et al. Specific and durable elimination of antibody to donor HLA antigens in renal-transplant patients. Transplantation. 2003. 76:1519–1525.

4. Rapaport FT. The case for a living emotionally related international kidney donor exchange registry. Transplant Proc. 1986. 18:Suppl 2. 5–9.

5. Montgomery RA, Zachary AA, Ratner LE, Segev DL, Hiller JM, Warren DS, et al. Clinical results from transplanting incompatible live kidney donor/recipient pairs using kidney paired donation. JAMA. 2005. 294:1655–1663.

6. de Klerk M, Keizer KM, Claas FH, Witvliet M, Haase-Kromwijk BJ, Weimar W. The Dutch national living donor kidney exchange program. Am J Transplant. 2005. 5:2302–2305.

7. Lucan M, Rotariu P, Neculoiu D, Iacob G. Kidney exchange program: a viable alternative in countries with low rate of cadaver harvesting. Transplant Proc. 2003. 35:933–934.

8. Park K, Moon JI, Kim SI, Kim YS. Exchange donor program in kidney transplantation. Transplantation. 1999. 67:336–338.

9. Kwak JY, Kwon OJ, Lee KS, Kang CM, Park HY, Kim JH. Exchange-donor program in renal transplantation: a single-center experience. Transplant Proc. 1999. 31:344–345.

10. Woodle ES, Boardman R, Bohnengel A, Downing K. Influence of educational programs on perceived barriers toward living donor kidney exchange programs. Transplant Proc. 2005. 37:602–604.

11. Saidman SL, Roth AE, Sonmez T, Unver MU, Delmonico FL. Increasing the opportunity of live kidney donation by matching for two- and three-way exchanges. Transplantation. 2006. 81:773–782.

12. Kaplan I, Houp JA, Montgomery RA, Leffell MS, Hart JM, Zachary AA. A computer match program for paired and unconventional kidney exchanges. Am J Transplant. 2005. 5:2306–2308.

13. Metzger RA, Delmonico FL, Feng S, Port FK, Wynn JJ, Merion RM. Expanded criteria donors for kidney transplantation. Am J Transplant. 2003. 3:Suppl 4. 114–125.

14. Stratta RJ, Rohr MS, Sundberg AK, Armstrong G, Hairston G, Adams PL, et al. Increased kidney transplantation utilizing expanded criteria deceased organ donors with results comparable to standard criteria donor transplant. Ann Surg. 2004. 239:688–695.

15. Morrissey PE, Gohh R, Yango A, Gautam A, Monaco AP. Renal transplant survival from older donors: a single center experience. Arch Surg. 2004. 139:384–389.

16. Edwards EB, Posner MP, Maluf DG, Kauffman HM. Reasons for non-use of recovered kidneys: the effect of donor glomerulosclerosis and creatinine clearance on graft survival. Transplantation. 2004. 77:1411–1415.

17. Singh D, Kiberd B, Lawen J. Can the outcome of older donor kidneys in transplantation be predicted? An analysis of existing scoring systems. Clin Transplant. 2004. 8:351–356.

18. Cooper JT, Chin LT, Krieger NR, Fernandez LA, Foley DP, D'Alessandro AM, et al. Donation after cardiac death: the university of wisconsin experience with renal transplantation. Am J Transplant. 2004. 4:1490–1494.

19. Yopp AC, Krieger NR, Ochando JC, Bromberg JS. Therapeutic manipulation of T cell chemotaxis in transplantation. Curr Opin Immunol. 2004. 16:571–577.

20. Grohmann U, Orabona C, Fallarino F, Vacca C, Calcinaro F, Puccetti P, et al. CTLA-4-Ig regulates tryptophan catabolism in vivo. Nat Immunol. 2002. 3:1097–1101.

21. Tedesco-Silva H, Mourad G, Kahan BD, Boira JG, Weimar W, Vanrenterghem Y, et al. FTY720, a novel immunomodulator: efficacy and safety results from the first phase 2A study in de novo renal transplantation. Transplantation. 2004. 77:1826–1833.

22. Larsen CP, Elwood ET, Alexander DZ, Ritchie SC, Hendrix R, Pearson TC, et al. Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways. Nature. 1996. 381:434–438.

23. Wood KJ, Luo S, Akl A. Regulatory T cells: potential in organ transplantation. Transplantation. 2004. 77:Suppl 1. S6–S8.

24. Ojo AO, Held PJ, Port FK, Wolfe RA, Leichtman AB, Merion RM, et al. Chronic renal failure after transplantation of a nonrenal organ. N Engl J Med. 2003. 349:931–940.

25. Suwelack B, Gerhardt U, Hohage H. Withdrawal of cyclosporine or tacrolimus after addition of mycophenolate mofetil in patients with chronic allograft nephropathy. Am J Transplant. 2004. 4:655–662.

26. Mota A, Arias M, Taskinen EI, Paavonen T, Brault Y, Neylan JF, et al. Sirolimus-based therapy following early cyclosporine withdrawal provides significantly improved renal histology and function at 3 years. Am J Transplant. 2004. 4:953–961.

27. Flechner SM, Kurian SM, Solez K, Cook DJ, Burke JT, Salomon DR, et al. De novo kidney transplantation without use of calcineurin inhibitors preserves renal structure and function at two years. Am J Transplant. 2004. 4:1776–1785.

28. Sarwal MM, Vidhun JR, Alexander SR, Satterwhite T, Millan M, Salvatierra O Jr. Continued superior outcomes with modification and lengthened follow-up of a steroid-avoidance pilot with extended daclizumab induction in pediatric renal transplantation. Transplantation. 2003. 76:1331–1339.

29. Zhou P, Hwang KW, Palucki D, Kim O, Newell KA, Alegre ML, et al. Secondary lymphoid organs are important but not absolutely required for allograft responses. Am J Transplant. 2003. 3:259–266.

30. Kreisel D, Krupnick AS, Balsara KR, Riha M, Gelman AE, Rosengard BR, et al. Mouse vascular endothelium activates CD8+ T lymphocytes in a B7-dependent fashion. J Immunol. 2002. 169:6154–6161.

31. Terasaki PI, Ozawa M. Predicting kidney graft failure by HLA antibodies: a prospective trial. Am J Transplant. 2004. 4:438–443.

32. Rha KH, Kim YS, Kim SI, Byun YJ, Hong SJ, Yang SC, et al. Video assisted minilaparotomy surgery (VAMS)-live donor nephrectomy: 239 cases. Yonsei Med J. 2004. 45:1149–1154.

33. Jordan SC, Vo A, Bunnapradist S, Toyoda M, Peng A, Tyan D, et al. Intravenous immune globulin treatment inhibits crossmatch positivity and allows for successful transplantation of incompatible organs in living-donor and cadaver recipients. Transplantation. 2003. 76:631–636.

34. Stegall MD, Dean PG, Gloor JM. ABO-incompatible kidney transplantation. Transplantation. 2004. 78:635–640.

35. Freeman RB Jr, Wiesner RH, Roberts JP, McDiarmid S, Dykstra DM, Merion RM. Improving liver allocation: MELD and PELD. Am J Transplant. 2004. 4:Suppl 9. 114–131.

36. Shapiro AM, Lakey JR, Ryan EA, Korbutt GS, Toth E, Rajotte RV, et al. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N Engl J Med. 2000. 343:230–238.

37. Shapiro AM, Lakey JR, Paty BW, Senior PA, Bigam DL, Ryan EA. Strategic opportunities in clinical islet transplantation. Transplantation. 2005. 79:1304–1307.

38. Gaglia JL, Shapiro AM, Weir GC. Islet transplantation: progress and challenge. Arch Med Res. 2005. 36:273–280.

39. Gruessner RW, Sutherland DE, Parr E, Humar A, Gruessner AC. A prospective, randomized, open-label study of steroid withdrawal in pancreas transplantation-a preliminary report with 6-month follow-up. Transplant Proc. 2001. 33:1663–1664.