J Korean Med Assoc.  2015 Jun;58(6):516-522. 10.5124/jkma.2015.58.6.516.

Advances in magnetic resonance technique for tumor imaging

• Park DW

• KMID: 2137558
• DOI: http://doi.org/10.5124/jkma.2015.58.6.516

Abstract

The development of advanced magnetic resonance (MR) imaging techniques for tumors has not only lead to improved diagnostic accuracy, but has also assisted with tumor staging, surgical planning, and postoperative follow-up study. Recently introduced and/or clinically used MR imaging techniques for tumors, including chemical exchange saturation transfer imaging, molecular imaging, magnetic resonance spectroscopy, perfusion, and blood flow suppression techniques, could improve diagnostic accuracy and provide useful information to guide the management of tumors. It is essential to properly obtain and evaluate advanced MR images for tumors, depending on the specific characteristics of each tumor.

Keyword

Magnetic resonance imaging; Neoplasms; Chemical exchange saturation transfer imaging; Molecular imaging; Perfusion weighted magnetic resonance imaging

MeSH Terms

Magnetic Resonance Imaging
Molecular Imaging
Neoplasm Staging
Perfusion
Spectrum Analysis

Figure

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  Figure 1 A 42-year-old woman with recurred multicentric glioblastoma at the left frontal lobe and anterior body of right corpus callosum. The lesional extent of tumor (arrows) on chemical exchange saturation transfer image (A) is between that on T2 weighted image (B) and contrast-enhanced T1 weighted image (C).

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  Figure 2 A 71-year-old woman with right high parietal falcine meningioma. The tumor shows well-enhancing extraaxial mass on fluid attenuated inversion recovery (FLAIR) (A) and enhanced T1 weighted images (T1WIs) (B), which turns into isointense mass due to high concentration of contrast except surrounding meninges (arrow) on delayed enhanced FLAIR image (C). It is clearly defined on blood flow-suppressed, enhanced T1WI with improved motion-sensitized driven-equilibrium technique (D). Dynamic contrast enhanced perfusion study (E) shows hypervascular benign mass with the gradual perfusion increase. Chemical exchange saturation transfer image (F) presents focal faint color map, suggestive of benignancy with less production of abnormal tumor protein (arrow).

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  Figure 3 Schematic of a cancer-targeted imaging probe (peptide). The cancer-targeted antibody, peptide and magnetic resonance (MR) agent (contrast) are integrated into a single system, which acts as a molecular imaging platform. Ab, antibody; Ag, antigen.

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  Figure 4 A 63-year-old man with left parietal abscess (A) and 68-year-old man with left temporal glioblastoma (B). Magnetic resonance spectroscopy, point resolved spectroscopy sequence shows high peaks of succinate and aspartate on abscess (A) and high choline peak/low N-acetylaspartate peak on high grade tumor (B).

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  Figure 5 A 53-year-old woman with left cerebellar metastatic tumors from lung cancer. Small sized, well-enhancing metastatic tumors (arrows) are detected on enhanced T1 weighted image (A), which are additionally detected on improved motion-sensitized driven-equilibrium technique (B). It shows low signal rim on apparent diffusion coefficient map (C), suggesting high cellularity, with increased relative cerebral blood volume and early and rapidly increased permeability (blank arrow) and washout on dynamic susceptibility contrast enhanced (D) and dynamic contrast enhanced (E) perfusion magnetic resonance imaging.

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  Figure 6 A 37-year-old man with peripheral T-cell lymphoma (arrows) at both cerebellum. Tumors (arrows) are well detected on enhanced T1 weighted image with improved motion-sensitized driven-equilibrium technique (A), which are diffusivity restricted lesion with high signals on diffusion weighted image (B). They show increased perfusion on arterial spin labeling perfusion (C), relative cerebral blood volume map of dynamic susceptibility contrast enhanced perfusion (D) and dynamic contrast enhanced perfusion magnetic resonance imaging (E) with gradually delayed increased permeability (blank arrow).

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