J Korean Acad Rehabil Med.  1997 Oct;21(5):1039-1044.

Mononeuritis Multiplex in Association with Anti-neutrophil Cytoplasmic Autoantibody(?) Vasculitis: A case report

• Kim MS
• Kim HS
• Hwang CM
• Ahn KH

Abstract

Mononeuritis multiplex may be a manifestation of systemic vasculitis or of other illnesses such as sarcoidosis, diabetes, lymphoma, and AIDS. Anti-neutrophil cytoplasmic autoantibody(ANCA) is a serologic marker for pauci-immune crescentic glomerulonephritis and systemic necrotizing arteritis, including polyarteritis nodosa, Wegener's granulomatosis and so-called ANCA-associated vasculitis. We report a case of mononeuritis multiplex due to ANCA associated vasculitis. A 46-year-old female visited hospital because of peripheral edema, pain and dyspnea. We diagnosed neuropathy associated with vasculitis by electrophysiologic study, sural nerve biopsy and angiography. The patient was treated with prednisolone and cyclophosphamide. Her symptoms and signs improved and her ANCA test was converted from positive to negative.

Keyword

Mononeuritis multiplex; Vasculitis; Anti-neutrophil cytoplasmic autoantibody

MeSH Terms

Angiography
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
Antibodies, Antineutrophil Cytoplasmic
Biopsy
Cyclophosphamide
Cytoplasm*
Dyspnea
Edema
Female
Glomerulonephritis
Humans
Lymphoma
Middle Aged
Mononeuropathies*
Polyarteritis Nodosa
Prednisolone
Sarcoidosis
Sural Nerve
Systemic Vasculitis
Vasculitis*
Wegener Granulomatosis
Antibodies, Antineutrophil Cytoplasmic
Cyclophosphamide
Prednisolone