J Korean Acad Rehabil Med.  2001 Apr;25(2):330-335.

Mixed Quadriplegia with Lissencephaly and Dysmyelination

Affiliations
  • 1Department of Rehabilitation Medicine, The Catholic University of Korea, School of Medicine.

Abstract

Lissencephaly results from a neuromigrational arrest during first and second trimester of pregnancy and shows hypotonia, marked mental retardation and seizure as predominant features. Myelination is a perinatal process and co-occurence of migrational disorder with myelination disorder is rare. We report a 17-month-old male with mixed quadriplegia and mental retardation with type 1 lissencephaly and dysmyelination of cerebral white matter diagnosed by magnetic resonance imaging.

Keyword

Lissencephaly; Myelination disorder; Mixed quadriplegia; Magnetic resonance imaging

MeSH Terms

Classical Lissencephalies and Subcortical Band Heterotopias
Female
Humans
Infant
Intellectual Disability
Lissencephaly*
Magnetic Resonance Imaging
Male
Muscle Hypotonia
Myelin Sheath
Pregnancy
Pregnancy Trimester, Second
Quadriplegia*
Seizures
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