Korean J Perinatol.  2003 Dec;14(4):433-437.

A Case of Lissencephaly Dignosed by Magnetic Resonance Imaging

• Park IY
• Kim HJ
• Kim J
• Ahn HY
• Shin JC
• Kim SP

Abstract

Lissencephaly is a rare disorder that is characterized by the disorganized and unlayered cortex. The cause of this disorder is related to chromosomal abnormalities or infection. The pathogenesis of lissencephaly is faulty migration of neuroblast. Lissencephaly is associated with Dandy-Walker syndrome and Miller-Dieker syndrome. A woman at 35 weeks of gestaion was transferred to our hospital due to abnormal antenatal sonographic findings (ventricular dilation and decreased sulci in cerebral cortex after 31 weeks of gestation). The antenatal studies showed none-specific findings. The infant was diagnosed lissencephaly by postnatal MRI evaluation and showed normal karyotype. We report the prenatal diagnosis of lissencephaly case with a literature.

Keyword

Lissencephaly; Ventricular Dilation; Antenatal Diagnosis

MeSH Terms

Cerebral Cortex
Chromosome Aberrations
Classical Lissencephalies and Subcortical Band Heterotopias
Dandy-Walker Syndrome
Female
Humans
Infant
Karyotype
Lissencephaly*
Magnetic Resonance Imaging*
Prenatal Diagnosis
Ultrasonography