J Clin Pathol Qual Control.  2001 Dec;23(2):281-285.

Delta and Panic Value Check in Hyperuricemia -Tuberculosis Patients Treated with Pyrazinamide-

• Ryu JH
• Lee KR
• Kim JH
• Kwon OH
• Chang J

Abstract

BACKGROUND: Pyrazinamide (PZA) has been used for first-line treatment regimen of tuberculosis. It is well known that PZA causes hyperuricemia, but case studies were not properly performed in our country. We found that many cases of tuberculosis patients treated with PZA were related to the causes of delta and panic check failure of uric acid in our hospital. Therefore we studied frequency of hyperuricemia in tuberculosis patients treated with PZA and delta and panic value check in uric acid.
METHODS
We investigated serum uric acid level of 160 pulmonary tuberculosis patients admitted at Severance hospital from June 1998 through May 2000. Serum uric acid levels were measured by Hitachi 747 autoanalyzer using uricase method. The failure of delta and panic value check were reviewed for serum uric acid level from January 2000 through May 2000.
RESULTS
The mean serum levels of uric acid were significantly elevated in 94 (85.45%) of 110 patients who were treated with PZA (P < 0.05). The mean serum levels of uric acid in patients who were treated with other drugs (n=50) were not significantly different between before and after treatment. With respect to frequency of delta and panic value checking failure, uric acid constitutes 3.3% (1,845/56,136). Of the 1,845 cases, 131 were related to PZA (7.1%).
CONCLUSIONS
We found that PZA-induced hyperuricemia are frequently seen in pulmonary tuberculosis patients. Therefore we should consider PZA-induced hyperuricemia in tuberculosis patients as one of the causes of delta and panic check failure of uric acid in clinical laboratory.

MeSH Terms

Humans
Hyperuricemia*
Panic*
Pyrazinamide
Tuberculosis
Tuberculosis, Pulmonary
Urate Oxidase
Uric Acid
Pyrazinamide
Urate Oxidase
Uric Acid